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Maggi CA, Giuliani S, Meli A. The effect of peripherally administered GABA on noradrenaline-induced reflex vagal bradycardia in urethane anaesthetized rats. Gen Pharmacol. 1985;16(6):579-84doi: 10.1016/0306-3623(85)90146-6.
Maggi, C. A., Giuliani, S., & Meli, A. (1985). The effect of peripherally administered GABA on noradrenaline-induced reflex vagal bradycardia in urethane anaesthetized rats. General pharmacology, 16(6), 579-84. https://doi.org/10.1016/0306-3623(85)90146-6
Maggi, C A, et al. "The effect of peripherally administered GABA on noradrenaline-induced reflex vagal bradycardia in urethane anaesthetized rats." General pharmacology vol. 16,6 (1985): 579-84. doi: https://doi.org/10.1016/0306-3623(85)90146-6
Maggi CA, Giuliani S, Meli A. The effect of peripherally administered GABA on noradrenaline-induced reflex vagal bradycardia in urethane anaesthetized rats. Gen Pharmacol. 1985;16(6):579-84. doi: 10.1016/0306-3623(85)90146-6. PMID: 2867949.
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Elsevier Science

Gen Pharmacol. 1985;16(6):579-84. doi: 10.1016/0306-3623(85)90146-6.

The effect of peripherally administered GABA on noradrenaline-induced reflex vagal bradycardia in urethane anaesthetized rats.

General pharmacology

C A Maggi, S Giuliani, A Meli

PMID: 2867949 DOI: 10.1016/0306-3623(85)90146-6

Abstract

Intravenously administered GABA significantly reduced the size of noradrenaline-induced reflex vagal bradycardia without affecting blood pressure increase. Intravenously administered GABA reduced bradycardia elicited by stimulation of preganglionic fibres in the vagus nerve. These findings provide evidence suggesting that, in addition to its well known effects on structures regulation cardiovascular function at CNS level GABA could modulate baroreceptor reflex(es) by acting at a peripheral site.

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