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Am J Physiol Heart Circ Physiol. 2020 Aug 01;319(2):H396-H409. doi: 10.1152/ajpheart.00112.2020. Epub 2020 Jul 17.

Attenuating loss of cardiac conduction during no-flow ischemia through changes in perfusate sodium and calcium.

American journal of physiology. Heart and circulatory physiology

Gregory S Hoeker, Carissa C James, Allison N Tegge, Robert G Gourdie, James W Smyth, Steven Poelzing

Affiliations

  1. Center for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia.
  2. Translational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Roanoke, Virginia.
  3. Virginia Tech Carilion School of Medicine, Roanoke, Virginia.
  4. Department of Statistics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.
  5. Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.
  6. Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.

PMID: 32678707 PMCID: PMC7473923 DOI: 10.1152/ajpheart.00112.2020

Abstract

Myocardial ischemia leads to conduction slowing, cell-to-cell uncoupling, and arrhythmias. We previously demonstrated that varying perfusate sodium (Na

Keywords: arrhythmia; calcium; conduction; ischemia; sodium

References

  1. Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1190-H1198 - PubMed
  2. Am J Physiol. 1951 Jun;165(3):505-12 - PubMed
  3. Pflugers Arch. 2015 Oct;467(10):2093-105 - PubMed
  4. Circulation. 1979 Aug;60(2):397-403 - PubMed
  5. J Cardiovasc Electrophysiol. 1996 Dec;7(12):1172-82 - PubMed
  6. Am Heart J. 1985 Feb;109(2):290-6 - PubMed
  7. J Physiol. 2018 Feb 15;596(4):563-589 - PubMed
  8. Br J Pharmacol. 2011 Jun;163(3):469-83 - PubMed
  9. Mol Biol Cell. 2011 May;22(9):1516-28 - PubMed
  10. Naunyn Schmiedebergs Arch Pharmacol. 2010 Mar;381(3):221-34 - PubMed
  11. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20935-40 - PubMed
  12. Circulation. 1986 Jan;73(1):189-98 - PubMed
  13. Circ Res. 1989 Oct;65(4):1029-44 - PubMed
  14. J Physiol. 1955 Sep 28;129(3):568-82 - PubMed
  15. Stroke. 1983 Mar-Apr;14(2):219-26 - PubMed
  16. Circ Res. 1984 Jan;54(1):10-20 - PubMed
  17. Cell Commun Adhes. 2014 Jun;21(3):161-7 - PubMed
  18. Circulation. 1975 Jun;51(6):1003-14 - PubMed
  19. Circ Res. 1991 Jan;68(1):255-62 - PubMed
  20. Exp Physiol. 2004 Mar;89(2):163-72 - PubMed
  21. J Physiol. 1978 Sep;282:333-43 - PubMed
  22. Physiol Rep. 2017 Jan;5(1): - PubMed
  23. Circ Res. 1987 Aug;61(2):271-9 - PubMed
  24. J Am Coll Cardiol. 2007 Mar 27;49(12):1299-305 - PubMed
  25. Circ Res. 1990 Apr;66(4):913-31 - PubMed
  26. Front Physiol. 2018 May 04;9:398 - PubMed
  27. Circulation. 1988 Jun;77(6):1385-94 - PubMed
  28. Circulation. 1977 Aug;56(2):217-24 - PubMed
  29. Circ Res. 1982 Nov;51(5):637-51 - PubMed
  30. J Mol Cell Cardiol. 1996 Jan;28(1):123-31 - PubMed
  31. Am J Cardiol. 1977 Apr;39(4):544-9 - PubMed
  32. Pflugers Arch. 2016 Oct;468(10):1651-61 - PubMed
  33. J Membr Biol. 1984;78(2):163-8 - PubMed
  34. Circ Res. 1983 Aug;53(2):176-85 - PubMed
  35. Front Physiol. 2017 May 23;8:334 - PubMed
  36. Circulation. 1980 Apr;61(4):768-78 - PubMed
  37. J Electrocardiol. 2005 Oct;38(4 Suppl):52-4 - PubMed
  38. Circulation. 1996 Feb 1;93(3):603-13 - PubMed
  39. Circulation. 1987 Nov;76(5):1146-54 - PubMed
  40. Circ Res. 1981 Oct;49(4):901-11 - PubMed
  41. Helv Physiol Pharmacol Acta. 1948;6(2):208-21 - PubMed
  42. PLoS Comput Biol. 2019 May 31;15(5):e1007042 - PubMed
  43. Circ Res. 1981 Nov;49(5):1069-81 - PubMed
  44. Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1129-39 - PubMed
  45. Elife. 2018 Aug 14;7: - PubMed
  46. Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H849-H861 - PubMed
  47. J Cardiovasc Electrophysiol. 1996 Nov;7(11):1024-38 - PubMed
  48. Science. 1954 Feb 12;119(3085):200-3 - PubMed
  49. Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H214-21 - PubMed
  50. IEEE Trans Biomed Eng. 2013 Feb;60(2):576-82 - PubMed
  51. Prog Biophys Mol Biol. 1980;36(1):1-52 - PubMed
  52. Circ Res. 1989 Jul;65(1):95-102 - PubMed
  53. J Clin Invest. 1976 Mar;57(3):541-50 - PubMed
  54. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H278-86 - PubMed
  55. Circulation. 2018 Mar 20;137(12):e67-e492 - PubMed
  56. Front Physiol. 2016 Feb 02;7:16 - PubMed
  57. Trends Cardiovasc Med. 2013 Aug;23(6):222-8 - PubMed
  58. Pflugers Arch. 2015 Nov;467(11):2287-97 - PubMed
  59. Cardiovasc Res. 1994 Dec;28(12):1737-44: discussion 1745-6 - PubMed
  60. FASEB J. 2003 Jul;17(10):1355-7 - PubMed
  61. Circ Res. 1970 May;26(5):565-74 - PubMed
  62. J Theor Biol. 2016 May 21;397:103-14 - PubMed
  63. Circ Arrhythm Electrophysiol. 2017 Feb;10(2):e004400 - PubMed
  64. Anesthesiology. 1999 Mar;90(3):812-21 - PubMed
  65. Biophys J. 2014 Feb 18;106(4):925-31 - PubMed
  66. Prog Biophys Mol Biol. 2016 Jan;120(1-3):189-98 - PubMed
  67. J Physiol. 1983 Dec;345:391-407 - PubMed
  68. IEEE Trans Biomed Eng. 1998 May;45(5):563-71 - PubMed
  69. Basic Clin Pharmacol Toxicol. 2007 Oct;101(4):215-30 - PubMed
  70. J Mol Cell Cardiol. 2006 Jun;40(6):790-8 - PubMed
  71. Front Physiol. 2019 Dec 10;10:1487 - PubMed
  72. Circ Res. 1982 Nov;51(5):614-23 - PubMed
  73. Nat Rev Drug Discov. 2018 Dec;17(12):905-921 - PubMed
  74. Nat Commun. 2016 Jan 20;7:10342 - PubMed
  75. Circulation. 1984 Jul;70(1):149-51 - PubMed
  76. Am J Cardiol. 1974 Apr;33(4):529-40 - PubMed
  77. Circulation. 1996 Jul 1;94(1):10-3 - PubMed
  78. Heart Rhythm. 2012 Sep;9(9):1493-500 - PubMed
  79. Chaos. 2017 Sep;27(9):093908 - PubMed
  80. Circ Res. 2000 Oct 13;87(8):656-62 - PubMed
  81. Circ Res. 1990 Jun;66(6):1461-73 - PubMed
  82. Circ Res. 1978 Jul;43(1):125-35 - PubMed
  83. J Vis Exp. 2018 Sep 28;(139): - PubMed
  84. Am J Physiol. 1991 Dec;261(6 Pt 2):H2008-15 - PubMed

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