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Kirchheim H, Ehmke H, Persson P. Physiology of the renal baroreceptor mechanism of renin release and its role in congestive heart failure. Am J Cardiol. 1988;62(8):68E-71Edoi: 10.1016/s0002-9149(88)80015-8.
Kirchheim, H., Ehmke, H., & Persson, P. (1988). Physiology of the renal baroreceptor mechanism of renin release and its role in congestive heart failure. The American journal of cardiology, 62(8), 68E-71E. https://doi.org/10.1016/s0002-9149(88)80015-8
Kirchheim, H, et al. "Physiology of the renal baroreceptor mechanism of renin release and its role in congestive heart failure." The American journal of cardiology vol. 62,8 (1988): 68E-71E. doi: https://doi.org/10.1016/s0002-9149(88)80015-8
Kirchheim H, Ehmke H, Persson P. Physiology of the renal baroreceptor mechanism of renin release and its role in congestive heart failure. Am J Cardiol. 1988 Sep 09;62(8):68E-71E. doi: 10.1016/s0002-9149(88)80015-8. PMID: 3046292.
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Elsevier Science

Am J Cardiol. 1988 Sep 09;62(8):68E-71E. doi: 10.1016/s0002-9149(88)80015-8.

Physiology of the renal baroreceptor mechanism of renin release and its role in congestive heart failure.

The American journal of cardiology

H Kirchheim, H Ehmke, P Persson

Affiliations

  1. I. Physiologisches Institut der Universität Heidelberg, Federal Republic of Germany.

PMID: 3046292 DOI: 10.1016/s0002-9149(88)80015-8

Abstract

The function of the renal baroreceptor can be quantitatively described by a stimulus-response curve showing a flat section in the high pressure range, a steep slope in the low pressure range, and a well-defined threshold pressure slightly below resting systemic pressure. This stimulus-response curve shows a close functional relation to autoregulation of renal blood flow, glomerular filtration rate and sodium excretion. Threshold pressure and slope are subject to different physiologic control mechanisms: The slope is increased by a low sodium diet, whereas threshold pressure is elevated by an increased renal sympathetic nerve discharge or by circulating catecholamines. Sympathetic influences also reset renal autoregulation. Recent studies have provided evidence for an important role of the renal baroreceptor in the long-term control of arterial blood pressure. The sympathetic modulation of threshold pressure can induce sodium retention in early heart failure, and the sympathetic effects on autoregulation may help to explain clinical reports on a deterioration of renal function during converting-enzyme therapy.

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