Display options
Cite
Schlegel ML, Spetz JF, Robel P, et al. Studies on the effects of dehydroepiandrosterone and its metabolites on attack by castrated mice on lactating intruders. Physiol Behav. 1985;34(6):867-70doi: 10.1016/0031-9384(85)90005-8.
Schlegel, M. L., Spetz, J. F., Robel, P., & Haug, M. (1985). Studies on the effects of dehydroepiandrosterone and its metabolites on attack by castrated mice on lactating intruders. Physiology & behavior, 34(6), 867-70. https://doi.org/10.1016/0031-9384(85)90005-8
Schlegel, M L, et al. "Studies on the effects of dehydroepiandrosterone and its metabolites on attack by castrated mice on lactating intruders." Physiology & behavior vol. 34,6 (1985): 867-70. doi: https://doi.org/10.1016/0031-9384(85)90005-8
Schlegel ML, Spetz JF, Robel P, Haug M. Studies on the effects of dehydroepiandrosterone and its metabolites on attack by castrated mice on lactating intruders. Physiol Behav. 1985 Jun;34(6):867-70. doi: 10.1016/0031-9384(85)90005-8. PMID: 2932747.
Copy Download .nbib Format: NLM
Share it on
Full text links
Elsevier Science

Physiol Behav. 1985 Jun;34(6):867-70. doi: 10.1016/0031-9384(85)90005-8.

Studies on the effects of dehydroepiandrosterone and its metabolites on attack by castrated mice on lactating intruders.

Physiology & behavior

M L Schlegel, J F Spetz, P Robel, M Haug

PMID: 2932747 DOI: 10.1016/0031-9384(85)90005-8

Abstract

Triads of castrated male mice (residents) were injected each day for 2 weeks with oil vehicle or 280 nmol of dehydroepiandrosterone (D). They were tested for their attack on a lactating female (intruder) introduced in their home-cage 2,24 or 48 hr after their last injection. D significantly reduced male aggressive behavior for at least 24 hr. Other groups of castrated males were injected each day with vehicle or 280 nmol of D, dehydroepiandrosterone sulfate (DS) or androstenediol (ADIOL). D, but neither DS nor ADIOL, significantly reduced their aggressive responses to intruders. Neural levels of D, DS and testosterone (T) were measured in intact males injected with vehicle or D. The concentration of D in brain was unchanged by castration and was increased about 20 fold in D injected males. The concentration of neural T was 10 nmol/g of tissue in intact males, was almost undetectable in castrated males, and was slightly increased in D injected males. Further work will be needed to identify the steroid molecule(s) responsible for this behavioral effect of D.

Cited by

Substances

MeSH terms

Publication Types

LinkOut - more resources