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Ammer-Herrmenau C, Pfisterer N, Weingarten MF, et al. The microbiome in pancreatic diseases: Recent advances and future perspectives. United European Gastroenterol J. 2020;8(8):878-885doi: 10.1177/2050640620944720.
Ammer-Herrmenau, C., Pfisterer, N., Weingarten, M. F., & Neesse, A. (2020). The microbiome in pancreatic diseases: Recent advances and future perspectives. United European gastroenterology journal, 8(8), 878-885. https://doi.org/10.1177/2050640620944720
Ammer-Herrmenau, Christoph, et al. "The microbiome in pancreatic diseases: Recent advances and future perspectives." United European gastroenterology journal vol. 8,8 (2020): 878-885. doi: https://doi.org/10.1177/2050640620944720
Ammer-Herrmenau C, Pfisterer N, Weingarten MF, Neesse A. The microbiome in pancreatic diseases: Recent advances and future perspectives. United European Gastroenterol J. 2020 Oct;8(8):878-885. doi: 10.1177/2050640620944720. Epub 2020 Jul 23. PMID: 32703080; PMCID: PMC7707879.
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United European Gastroenterol J. 2020 Oct;8(8):878-885. doi: 10.1177/2050640620944720. Epub 2020 Jul 23.

The microbiome in pancreatic diseases: Recent advances and future perspectives.

United European gastroenterology journal

Christoph Ammer-Herrmenau, Nina Pfisterer, Mark Fj Weingarten, Albrecht Neesse

Affiliations

  1. Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Centre Goettingen, Goettingen, Germany.

PMID: 32703080 PMCID: PMC7707879 DOI: 10.1177/2050640620944720

Abstract

The human microbiota exerts multiple physiological functions such as the regulation of metabolic and inflammatory processes. High-throughput sequencing techniques such as next-generation sequencing have become widely available in preclinical and clinical settings and have exponentially increased our knowledge about the microbiome and its interaction with host cells and organisms. There is now emerging evidence that microorganisms also contribute to inflammatory and neoplastic diseases of the pancreas. This review summarizes current clinical and translational microbiome studies in acute and chronic pancreatitis as well as pancreatic cancer and provides evidence that the microbiome has a high potential for biomarker discovery. Furthermore, the intestinal and pancreas-specific microbiome may also become an integrative part of diagnostic and therapeutic approaches of pancreatic diseases in the near future.

Keywords: 16S rRNA sequencing; Pancreatic cancer; metagenomic sequencing; microbiome; pancreatitis

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