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La Montanara P, Hervera A, Baltussen LL, et al. Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models. Sci Transl Med. 2020;12(551)doi: 10.1126/scitranslmed.aax4846.
La Montanara, P., Hervera, A., Baltussen, L. L., Hutson, T. H., Palmisano, I., De Virgiliis, F., Kong, G., Chadwick, J., Gao, Y., Bartus, K., Majid, Q. A., Gorgoraptis, N., Wong, K., Downs, J., Pizzorusso, T., Ultanir, S. K., Leonard, H., Yu, H., Millar, D. S., Istvan, N., Mazarakis, N. D., & Di Giovanni, S. (2020). Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models. Science translational medicine, 12(551), . https://doi.org/10.1126/scitranslmed.aax4846
La Montanara, Paolo, et al. "Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models." Science translational medicine vol. 12,551 (2020). doi: https://doi.org/10.1126/scitranslmed.aax4846
La Montanara P, Hervera A, Baltussen LL, Hutson TH, Palmisano I, De Virgiliis F, Kong G, Chadwick J, Gao Y, Bartus K, Majid QA, Gorgoraptis N, Wong K, Downs J, Pizzorusso T, Ultanir SK, Leonard H, Yu H, Millar DS, Istvan N, Mazarakis ND, Di Giovanni S. Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models. Sci Transl Med. 2020 Jul 08;12(551). doi: 10.1126/scitranslmed.aax4846. PMID: 32641489; PMCID: PMC7116442.
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Sci Transl Med. 2020 Jul 08;12(551). doi: 10.1126/scitranslmed.aax4846.

Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models.

Science translational medicine

Paolo La Montanara, Arnau Hervera, Lucas L Baltussen, Thomas H Hutson, Ilaria Palmisano, Francesco De Virgiliis, Guiping Kong, Jessica Chadwick, Yunan Gao, Katalin Bartus, Qasim A Majid, Nikos Gorgoraptis, Kingsley Wong, Jenny Downs, Tommaso Pizzorusso, Sila K Ultanir, Helen Leonard, Hongwei Yu, David S Millar, Nagy Istvan, Nicholas D Mazarakis, Simone Di Giovanni

Affiliations

  1. Department of Brain Sciences, Division of Neuroscience, Imperial College London, London W12 0NN, UK. [email protected] [email protected].
  2. Department of Brain Sciences, Division of Neuroscience, Imperial College London, London W12 0NN, UK.
  3. Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
  4. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain.
  5. Department of Cell Biology, Physiology and Immunology, Faculty of Biology & Institute of Neuroscience, Universitat de Barcelona, 08028 Barcelona, Spain.
  6. Kinases and Brain Development Laboratory, Francis Crick Institute, London NW1 1AT, UK.
  7. Gene Therapy, Centre for Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Department of Medicine, Imperial College London, London W12 0NN, UK.
  8. Wolfson Centre for Age-Related Diseases, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK.
  9. National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
  10. Telethon Kids Institute, University of Western Australia, Perth, WA 6009, Australia.
  11. Institute of Neuroscience, National Research Council (CNR), I-56124 Pisa, Italy.
  12. Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, I-50135 Florence, Italy.
  13. Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  14. Institute of Cancer and Genetics, Cardiff University, Cardiff F14 4ED, UK.
  15. Nociception, Section of Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK.

PMID: 32641489 PMCID: PMC7116442 DOI: 10.1126/scitranslmed.aax4846

Abstract

Cyclin-dependent-like kinase 5 (

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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