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Kovar L, Schräpel C, Selzer D, et al. Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. Pharmaceutics. 2020;12(6)doi: 10.3390/pharmaceutics12060578.
Kovar, L., Schräpel, C., Selzer, D., Kohl, Y., Bals, R., Schwab, M., & Lehr, T. (2020). Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. Pharmaceutics, 12(6), . https://doi.org/10.3390/pharmaceutics12060578
Kovar, Lukas, et al. "Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates." Pharmaceutics vol. 12,6 (2020). doi: https://doi.org/10.3390/pharmaceutics12060578
Kovar L, Schräpel C, Selzer D, Kohl Y, Bals R, Schwab M, Lehr T. Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. Pharmaceutics. 2020 Jun 23;12(6). doi: 10.3390/pharmaceutics12060578. PMID: 32585880; PMCID: PMC7355427.
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Pharmaceutics. 2020 Jun 23;12(6). doi: 10.3390/pharmaceutics12060578.

Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates.

Pharmaceutics

Lukas Kovar, Christina Schräpel, Dominik Selzer, Yvonne Kohl, Robert Bals, Matthias Schwab, Thorsten Lehr

Affiliations

  1. Department of Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
  2. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.
  3. Fraunhofer Institute for Biomedical Engineering IBMT, 66280 Sulzbach, Germany.
  4. Department of Internal Medicine V, Saarland University, 66421 Homburg, Germany.
  5. Departments of Clinical Pharmacology, and Pharmacy and Biochemistry, University Tübingen, 72076 Tübingen, Germany.

PMID: 32585880 PMCID: PMC7355427 DOI: 10.3390/pharmaceutics12060578

Abstract

Buprenorphine plays a crucial role in the therapeutic management of pain in adults, adolescents and pediatric subpopulations. However, only few pharmacokinetic studies of buprenorphine in children, particularly neonates, are available as conducting clinical trials in this population is especially challenging. Physiologically-based pharmacokinetic (PBPK) modeling allows the prediction of drug exposure in pediatrics based on age-related physiological differences. The aim of this study was to predict the pharmacokinetics of buprenorphine in pediatrics with PBPK modeling. Moreover, the drug-drug interaction (DDI) potential of buprenorphine with CYP3A4 and P-glycoprotein perpetrator drugs should be elucidated. A PBPK model of buprenorphine and norbuprenorphine in adults has been developed and scaled to children and preterm neonates, accounting for age-related changes. One-hundred-percent of the predicted AUC

Keywords: buprenorphine; drug-drug interaction (DDI); norbuprenorphine; pediatric scaling; pharmacokinetics; physiologically based pharmacokinetic (PBPK) modeling

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