Display options
Cite
Acevedo CG, Contreras E. Possible involvement of adenine nucleotides in the neurotransmission of the mouse urinary bladder. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(2):357-61doi: 10.1016/0742-8413(85)90176-8.
Acevedo, C. G., & Contreras, E. (1985). Possible involvement of adenine nucleotides in the neurotransmission of the mouse urinary bladder. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 82(2), 357-61. https://doi.org/10.1016/0742-8413(85)90176-8
Acevedo, C G, and Contreras, E. "Possible involvement of adenine nucleotides in the neurotransmission of the mouse urinary bladder." Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology vol. 82,2 (1985): 357-61. doi: https://doi.org/10.1016/0742-8413(85)90176-8
Acevedo CG, Contreras E. Possible involvement of adenine nucleotides in the neurotransmission of the mouse urinary bladder. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(2):357-61. doi: 10.1016/0742-8413(85)90176-8. PMID: 2866909.
Copy Download .nbib Format: NLM
Share it on

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(2):357-61. doi: 10.1016/0742-8413(85)90176-8.

Possible involvement of adenine nucleotides in the neurotransmission of the mouse urinary bladder.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

C G Acevedo, E Contreras

PMID: 2866909 DOI: 10.1016/0742-8413(85)90176-8

Abstract

The urinary bladder of the mouse contracts to several agonists, namely acetylcholine, noradrenaline, adrenaline, histamine, angiotensin, serotonin, purine nucleotides and prostaglandin F2 alpha. Atropine partially reduced the contraction induced by electrical stimulation, whereas propranolol and tolazoline were ineffective. The atropine resistant component of the neurogenic response was reduced by indomethacin. Methysergide and diphenhydramine were ineffective. Desensitization of the bladder by alpha,beta-methylene ATP abolished the response to ATP and greatly reduced the non-adrenergic non-cholinergic component of the neurogenic response. The results suggest that ATP could be the transmitter responsible for the non-cholinergic non-adrenergic contraction of the mouse urinary bladder.

Substances

MeSH terms

Publication Types

LinkOut - more resources