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Rigby JW, Scott AK, Hawksworth GM, et al. A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects. Br J Clin Pharmacol. 1985;20(4):327-31doi: 10.1111/j.1365-2125.1985.tb05072.x.
Rigby, J. W., Scott, A. K., Hawksworth, G. M., & Petrie, J. C. (1985). A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects. British journal of clinical pharmacology, 20(4), 327-31. https://doi.org/10.1111/j.1365-2125.1985.tb05072.x
Rigby, J W, et al. "A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects." British journal of clinical pharmacology vol. 20,4 (1985): 327-31. doi: https://doi.org/10.1111/j.1365-2125.1985.tb05072.x
Rigby JW, Scott AK, Hawksworth GM, Petrie JC. A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects. Br J Clin Pharmacol. 1985 Oct;20(4):327-31. doi: 10.1111/j.1365-2125.1985.tb05072.x. PMID: 2866783; PMCID: PMC1400877.
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Wiley Free PMC Article

Br J Clin Pharmacol. 1985 Oct;20(4):327-31. doi: 10.1111/j.1365-2125.1985.tb05072.x.

A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects.

British journal of clinical pharmacology

J W Rigby, A K Scott, G M Hawksworth, J C Petrie

PMID: 2866783 PMCID: PMC1400877 DOI: 10.1111/j.1365-2125.1985.tb05072.x
Free PMC Article

Abstract

Six elderly patients with established hypertension and six young healthy subjects were studied after 8 days of treatment with atenolol 50 mg day-1, metoprolol 50 mg day-1, oxprenolol 80 mg day-1 and propranolol 80 mg day-1. The area under the blood concentration-time curve was increased in the elderly group for each drug, but the difference was statistically significant only for atenolol. The lower serum albumin concentrations in the elderly group did not result in a decrease in the percentage of propranolol or oxprenolol bound to serum proteins.

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