Neurosci Lett. 1988 Apr 22;87(1):23-8. doi: 10.1016/0304-3940(88)90139-5.

Effects of D-(-)-aminophosphonovalerate on behavioral and histological changes induced by systemic kainic acid.

Neuroscience letters

W Lason, J N Simpson, J F McGinty

PMID: 2898113 DOI: 10.1016/0304-3940(88)90139-5

Abstract

In rats, the seizures induced by systemic kainic acid (KA) are followed by extensive neuronal damage, notably in the hippocampal region. We report that the specific N-methyl-D-aspartate (NMDA) receptor antagonist, D-(-)-aminophosphonovalerate (D(-)APV), given i.c.v. prior to or 2 h after i.p. KA injection markedly protected CA1 but not other hippocampal neurons against degeneration. In contrast, D(-)APV had no effect on KA-induced wet dog shakes or on behavioral seizures. We conclude that NMDA receptors participate in the neurotoxic but not in the behavioral effects of systemic KA.

Substances

• Receptors, N-Methyl-D-Aspartate
• Receptors, Neurotransmitter
• 2-Amino-5-phosphonovalerate
• Valine
• Kainic Acid

MeSH terms

• 2-Amino-5-phosphonovalerate
• Animals
• Hippocampus / drug effects
• Hippocampus / pathology
• Hippocampus / physiopathology
• Injections, Intraperitoneal
• Kainic Acid / toxicity
• Male
• Rats
• Rats, Inbred Strains
• Receptors, N-Methyl-D-Aspartate
• Receptors, Neurotransmitter / drug effects
• Receptors, Neurotransmitter / physiology
• Seizures / chemically induced
• Seizures / physiopathology
• Valine / analogs & derivatives
• Valine / pharmacology

Publication Types

• Journal Article
• Research Support, U.S. Gov't, P.H.S.

Grant support

• DA 03982/DA/NIDA NIH HHS/United States

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