Display options
Cite
Douglass EC, Look AT, Webber B, et al. Hyperdiploidy and chromosomal rearrangements define the anaplastic variant of Wilms' tumor. J Clin Oncol. 1986;4(6):975-81doi: 10.1200/JCO.1986.4.6.975.
Douglass, E. C., Look, A. T., Webber, B., Parham, D., Wilimas, J. A., Green, A. A., & Roberson, P. K. (1986). Hyperdiploidy and chromosomal rearrangements define the anaplastic variant of Wilms' tumor. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 4(6), 975-81. https://doi.org/10.1200/JCO.1986.4.6.975
Douglass, E C, et al. "Hyperdiploidy and chromosomal rearrangements define the anaplastic variant of Wilms' tumor." Journal of clinical oncology : official journal of the American Society of Clinical Oncology vol. 4,6 (1986): 975-81. doi: https://doi.org/10.1200/JCO.1986.4.6.975
Douglass EC, Look AT, Webber B, Parham D, Wilimas JA, Green AA, Roberson PK. Hyperdiploidy and chromosomal rearrangements define the anaplastic variant of Wilms' tumor. J Clin Oncol. 1986 Jun;4(6):975-81. doi: 10.1200/JCO.1986.4.6.975. PMID: 3012007.
Copy Download .nbib Format: NLM
Share it on
Full text links
Atypon

J Clin Oncol. 1986 Jun;4(6):975-81. doi: 10.1200/JCO.1986.4.6.975.

Hyperdiploidy and chromosomal rearrangements define the anaplastic variant of Wilms' tumor.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

E C Douglass, A T Look, B Webber, D Parham, J A Wilimas, A A Green, P K Roberson

PMID: 3012007 DOI: 10.1200/JCO.1986.4.6.975

Abstract

Flow cytometric measurement of the DNA content of Wilms' tumor cells revealed a striking correspondence with the histologic subtype and treatment outcome. In the 48 cases studied, a hyperdiploid DNA content ranging from 1.7 to 3.2 times the result for normal diploid cells distinguished all but one of the ten anaplastic tumors. Lower values, from 1.0 to 1.4 times the diploid DNA content, characterized the nonanaplastic specimens. By Kaplan-Meier analysis, the probability of achieving 3 years of relapse-free survival was significantly lower in the group with higher DNA content (0.42 v 0.87, P less than .01). Analysis of banded chromosomes for a subset of 22 patients contributed important information beyond the flow cytometric study. Cases of anaplasia associated with poorer responses to therapy showed numerous complex translocations, whereas all others lacked such changes. By combining flow cytometric techniques and conventional methods of chromosome analysis, it should be possible to identify those patients with Wilms' tumor who are most likely to fail therapy. The biologic implication of these findings is that the development of clinical drug resistance in Wilms' tumor is a result of the genetic instability of the malignant clone.

Similar articles

Woods AD, Berlow NE, Ortiz MV, Dela Cruz F, Siddiquee A, Coutinho DF, Purohit R, Freier KET, Michalek JE, Lathara M, Matlock K, Srivivasa G, Royer-Pokora B, Veselska R, Kung AL, Keller C.
Pediatr Blood Cancer. 2022 Feb;69(2):e29401. doi: 10.1002/pbc.29401. Epub 2021 Oct 24.
PMID: 34693628

Woods AD, Berlow NE, Ortiz MV, Dela Cruz F, Siddiquee A, Coutinho DF, Purohit R, Freier KET, Michalek JE, Lathara M, Matlock K, Srivivasa G, Royer-Pokora B, Veselska R, Kung AL, Keller C.
Pediatr Blood Cancer. 2021 Oct 24;e29401. doi: 10.1002/pbc.29401. Epub 2021 Oct 24.
PMID: 34693628

MeSH terms

Publication Types

Grant support

LinkOut - more resources