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Meredith PA, Elliott HL, Kelman AW, et al. Pharmacokinetic and pharmacodynamic modelling of the alpha adrenoceptor antagonist doxazosin. Xenobiotica. 1988;18(1):123-9doi: 10.3109/00498258809055143.
Meredith, P. A., Elliott, H. L., Kelman, A. W., Vincent, J., & Reid, J. L. (1988). Pharmacokinetic and pharmacodynamic modelling of the alpha adrenoceptor antagonist doxazosin. Xenobiotica; the fate of foreign compounds in biological systems, 18(1), 123-9. https://doi.org/10.3109/00498258809055143
Meredith, P A, et al. "Pharmacokinetic and pharmacodynamic modelling of the alpha adrenoceptor antagonist doxazosin." Xenobiotica; the fate of foreign compounds in biological systems vol. 18,1 (1988): 123-9. doi: https://doi.org/10.3109/00498258809055143
Meredith PA, Elliott HL, Kelman AW, Vincent J, Reid JL. Pharmacokinetic and pharmacodynamic modelling of the alpha adrenoceptor antagonist doxazosin. Xenobiotica. 1988 Jan;18(1):123-9. doi: 10.3109/00498258809055143. PMID: 2895548.
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Xenobiotica. 1988 Jan;18(1):123-9. doi: 10.3109/00498258809055143.

Pharmacokinetic and pharmacodynamic modelling of the alpha adrenoceptor antagonist doxazosin.

Xenobiotica; the fate of foreign compounds in biological systems

P A Meredith, H L Elliott, A W Kelman, J Vincent, J L Reid

Affiliations

  1. University of Glasgow, Department of Materia Medica, Stobhill General Hospital, UK.

PMID: 2895548 DOI: 10.3109/00498258809055143

Abstract

1. The pharmacokinetic and pharmacodynamic profiles of intravenous and oral doxazosin were investigated in 6 normotensive volunteers. 2. The pharmacokinetics of i.v. and oral doxazosin were fitted simultaneously and independently. The parameters derived were in good agreement with a mean elimination half-life of 539 +/- 75 min, bioavailability of 0.65 +/- 0.11 and clearance of 140 +/- 26 ml/min. 3. Pharmacokinetic-pharmacodynamic modelling indicated that the sensitivities to oral and i.v. doxazosin in individual subjects were in good agreement. 4. Based on these findings it is unlikely that doxazosin metabolites contribute significantly to the pharmacodynamic profile of doxazosin.

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