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Simental-Mendía M, Sánchez-García A, Simental-Mendía LE. Effect of ursodeoxycholic acid on liver markers: A systematic review and meta-analysis of randomized placebo-controlled clinical trials. Br J Clin Pharmacol. 2020;86(8):1476-1488doi: 10.1111/bcp.14311.
Simental-Mendía, M., Sánchez-García, A., & Simental-Mendía, L. E. (2020). Effect of ursodeoxycholic acid on liver markers: A systematic review and meta-analysis of randomized placebo-controlled clinical trials. British journal of clinical pharmacology, 86(8), 1476-1488. https://doi.org/10.1111/bcp.14311
Simental-Mendía, Mario, et al. "Effect of ursodeoxycholic acid on liver markers: A systematic review and meta-analysis of randomized placebo-controlled clinical trials." British journal of clinical pharmacology vol. 86,8 (2020): 1476-1488. doi: https://doi.org/10.1111/bcp.14311
Simental-Mendía M, Sánchez-García A, Simental-Mendía LE. Effect of ursodeoxycholic acid on liver markers: A systematic review and meta-analysis of randomized placebo-controlled clinical trials. Br J Clin Pharmacol. 2020 Aug;86(8):1476-1488. doi: 10.1111/bcp.14311. Epub 2020 Apr 27. PMID: 32285958; PMCID: PMC7373700.
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Br J Clin Pharmacol. 2020 Aug;86(8):1476-1488. doi: 10.1111/bcp.14311. Epub 2020 Apr 27.

Effect of ursodeoxycholic acid on liver markers: A systematic review and meta-analysis of randomized placebo-controlled clinical trials.

British journal of clinical pharmacology

Mario Simental-Mendía, Adriana Sánchez-García, Luis E Simental-Mendía

Affiliations

  1. Department of Orthopedics and Traumatology, Hospital Universitario "Dr. José E. González", Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.
  2. Endocrinology Division, Hospital Universitario "Dr. José E. González", Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.
  3. Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Mexico.

PMID: 32285958 PMCID: PMC7373700 DOI: 10.1111/bcp.14311

Abstract

AIM: The objective of this meta-analysis was to evaluate the effect of ursodeoxycholic acid (UDCA) therapy on serum liver function tests.

METHODS: PubMed, Web of Science, Scopus and Google Scholar databases were searched to identify randomized placebo-controlled trials assessing the impact of UDCA on hepatic parameters. Meta-analysis was conducted using a random-effects model and sensitivity analysis through the leave-one-out method in the Review Manager statistical software version 5.3.

RESULTS: After UDCA treatment, meta-analysis revealed a significant reduction of alanine aminotransferase (weighted mean difference [WMD]: -15.28 U/L, 95% confidence interval [CI]: -23.42, -7.15, P = 0.0002, I

CONCLUSION: The results of the present meta-analysis suggest a hepatoprotective effect of UDCA by reducing serum liver parameters.

© 2020 The British Pharmacological Society.

Keywords: hepatic function; meta-analysis; ursodeoxycholic acid

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