Can J Physiol Pharmacol. 1987 Apr;65(4):532-7. doi: 10.1139/y87-090.

Effects of autonomic stimulation on plasma immunoreactive atrial natriuretic peptide in the anesthetized rabbit.

Canadian journal of physiology and pharmacology

A J Rankin, N Wilson, J R Ledsome

PMID: 2955863 DOI: 10.1139/y87-090

Abstract

Infusions of norepinephrine led to a significant sevenfold increase in plasma immunoreactive atrial natriuretic peptide, while infusions of acetylcholine caused no significant change in the level of the peptide. Efferent stimulation of the right vagus nerve or right inferior cervical ganglion in anesthetized, vagotomized rabbits produced no significant changes in the immunoreactive atrial natriuretic peptide. The findings suggest that the mechanism by which norepinephrine releases immunoreactive atrial natriuretic peptide is not the result of a direct action on the cardiac myocytes.

Substances

• Atrial Natriuretic Factor
• Acetylcholine
• Norepinephrine

MeSH terms

• Acetylcholine / pharmacology
• Animals
• Atrial Natriuretic Factor / blood
• Autonomic Nervous System / drug effects
• Autonomic Nervous System / physiology
• Electric Stimulation
• Ganglia, Sympathetic / physiology
• Heart / drug effects
• Heart / innervation
• Male
• Norepinephrine / pharmacology
• Rabbits
• Sympathetic Nervous System / physiology
• Vagus Nerve / physiology

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't

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