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Iwai M, Jungermann K. Leukotrienes increase glucose and lactate output and decrease flow in perfused rat liver. Biochem Biophys Res Commun. 1988;151(1):283-90doi: 10.1016/0006-291x(88)90591-8.
Iwai, M., & Jungermann, K. (1988). Leukotrienes increase glucose and lactate output and decrease flow in perfused rat liver. Biochemical and biophysical research communications, 151(1), 283-90. https://doi.org/10.1016/0006-291x(88)90591-8
Iwai, M, and Jungermann, K. "Leukotrienes increase glucose and lactate output and decrease flow in perfused rat liver." Biochemical and biophysical research communications vol. 151,1 (1988): 283-90. doi: https://doi.org/10.1016/0006-291x(88)90591-8
Iwai M, Jungermann K. Leukotrienes increase glucose and lactate output and decrease flow in perfused rat liver. Biochem Biophys Res Commun. 1988 Feb 29;151(1):283-90. doi: 10.1016/0006-291x(88)90591-8. PMID: 2831885.
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Biochem Biophys Res Commun. 1988 Feb 29;151(1):283-90. doi: 10.1016/0006-291x(88)90591-8.

Leukotrienes increase glucose and lactate output and decrease flow in perfused rat liver.

Biochemical and biophysical research communications

M Iwai, K Jungermann

Affiliations

  1. Institut für Biochemie, Universität Göttingen, Germany.

PMID: 2831885 DOI: 10.1016/0006-291x(88)90591-8

Abstract

In isolated perfused rat liver leukotriene C4 and D4 but not B4 and E4 enhanced glucose and lactate output and lowered perfusion flow similar to the thromboxane A2 analogue U46619, extracellular ATP and prostaglandin F2 alpha. The kinetics of the metabolic changes caused by leukotriene C4 and D4 resembled those effected by U46619 and ATP but not those elicited by prostaglandin F2 alpha; the kinetics of the hemodynamic changes were similar only to those caused by U46619. The results show that leukotrienes could be important modulators of hepatic metabolism and hemodynamics and point to a complex intra-organ cell-cell communication between non-parenchymal and parenchymal cells.

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