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Šálek T, Adamíková A, Ponížil P. The fat mass, estimated glomerular filtration rate, and chronic inflammation in type 2 diabetic patients. J Clin Lab Anal. 2020;34(6):e23229doi: 10.1002/jcla.23229.
Šálek, T., Adamíková, A., & Ponížil, P. (2020). The fat mass, estimated glomerular filtration rate, and chronic inflammation in type 2 diabetic patients. Journal of clinical laboratory analysis, 34(6), e23229. https://doi.org/10.1002/jcla.23229
Šálek, Tomáš, et al. "The fat mass, estimated glomerular filtration rate, and chronic inflammation in type 2 diabetic patients." Journal of clinical laboratory analysis vol. 34,6 (2020): e23229. doi: https://doi.org/10.1002/jcla.23229
Šálek T, Adamíková A, Ponížil P. The fat mass, estimated glomerular filtration rate, and chronic inflammation in type 2 diabetic patients. J Clin Lab Anal. 2020 Jun;34(6):e23229. doi: 10.1002/jcla.23229. Epub 2020 Feb 11. PMID: 32045056; PMCID: PMC7307376.
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J Clin Lab Anal. 2020 Jun;34(6):e23229. doi: 10.1002/jcla.23229. Epub 2020 Feb 11.

The fat mass, estimated glomerular filtration rate, and chronic inflammation in type 2 diabetic patients.

Journal of clinical laboratory analysis

Tomáš Šálek, Alena Adamíková, Petr Ponížil

Affiliations

  1. Department of Clinical Biochemistry and Pharmacology, Tomas Bata Hospital in Zlín, Zlín, Czech Republic.
  2. Department of Biomedical sciences, Medical Faculty of the University of Ostrava, Ostrava, Czech Republic.
  3. Diabetes Centre, Tomas Bata Hospital in Zlín, Zlín, Czech Republic.
  4. Department of Physics & Material Engineering, Faculty of Technology, Tomas Bata University in Zlín, Zlín, Czech Republic.
  5. Centre of Polymer Systems, Tomas Bata University in Zlín, Zlín, Czech Republic.

PMID: 32045056 PMCID: PMC7307376 DOI: 10.1002/jcla.23229

Abstract

BACKGROUND: The aim of the study was to analyze the degree of obesity and its associations with age, gender, inflammation, an estimated glomerular filtration rate (eGFR), and liver function in type 2 diabetes mellitus (T2DM) patients.

METHODS: A total of 874 consecutive adult Caucasian T2DM patients from outpatient diabetic clinic were included in the study. The relative fat mass (RFM) and body mass index (BMI) were used as obesity markers. Serum creatinine and cystatin C were used for the GFR estimation. Serum high-sensitive C-reactive protein (hsCRP) was used as the indicator of inflammation.

RESULTS: The median, interquartile range (IQR) of RFM in females was higher than that in males (44.8 (42.3-47.2) % vs 31.3 (28.8-34.1) %, respectively; P < .0001). The median (IQR) of BMI in females was no higher than that in males (30 (27-34) kg/m

CONCLUSION: The RFM equation leads to higher obesity prevalence compared to BMI. Women have higher RFM compared to men. The kidney function was positively correlated with ALT serum concentrations.

© 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.

Keywords: abdominal fat; adipose tissue; alanine transaminase; body mass index; cystatin C; diabetes mellitus; glomerular filtration rate; inflammation; kidney diseases; obesity

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