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Abualhasan M, Odeh NW, Younis GN, et al. Analytical Method Development for Sodium Valproate through Chemical Derivatization. Int J Anal Chem. 2020;2020:5672183doi: 10.1155/2020/5672183.
Abualhasan, M., Odeh, N. W., Younis, G. N., & Zeidan, O. F. (2020). Analytical Method Development for Sodium Valproate through Chemical Derivatization. International journal of analytical chemistry, 20205672183. https://doi.org/10.1155/2020/5672183
Abualhasan, Murad, et al. "Analytical Method Development for Sodium Valproate through Chemical Derivatization." International journal of analytical chemistry vol. 2020 (2020): 5672183. doi: https://doi.org/10.1155/2020/5672183
Abualhasan M, Odeh NW, Younis GN, Zeidan OF. Analytical Method Development for Sodium Valproate through Chemical Derivatization. Int J Anal Chem. 2020 Jan 31;2020:5672183. doi: 10.1155/2020/5672183. eCollection 2020. PMID: 32099545; PMCID: PMC7013335.
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Int J Anal Chem. 2020 Jan 31;2020:5672183. doi: 10.1155/2020/5672183. eCollection 2020.

Analytical Method Development for Sodium Valproate through Chemical Derivatization.

International journal of analytical chemistry

Murad Abualhasan, Nihaya Wasif Odeh, Ghadeer Naser Younis, Oyoun Fadel Zeidan

Affiliations

  1. Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, State of Palestine.

PMID: 32099545 PMCID: PMC7013335 DOI: 10.1155/2020/5672183

Abstract

BACKGROUND: Sodium valproate has anticonvulsant activity and is structurally different to conventional antiepileptic drugs. The problem with valproic acid is the lack of a chromophore, which means that gas chromatography is the sole assay methodology. The introduction of benzoyl and phenyl groups to the molecule is a useful derivatisation, which enables the creation of detectable chromophores for HPLC analysis for pharmaceutical dosages as well as biological systems.

RESULTS: The developed method was easy and feasible and can be applied to both routine analysis and bioanalysis. The method was very sensitive and could quantify valproic acid at a very low concentration of 0.75 × 10

CONCLUSION: The proposed chemical derivatisation and the developed analytical method are novel. The developed analytical procedure is the first of its kind; it is easy and feasible and can be used to quantify and detect sodium valproate at very low concentrations compared to other available methods in the literature.

Copyright © 2020 Murad Abualhasan et al.

Conflict of interest statement

There are no conflicts of interest regarding the publication of this paper.

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