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Kazemi NY, Jain C, Bois MC, et al. Heart Block Caused by Cardiac Metastasis From Merkel Cell Carcinoma: A Case Report. Mayo Clin Proc Innov Qual Outcomes. 2019;3(4):510-516doi: 10.1016/j.mayocpiqo.2019.09.005.
Kazemi, N. Y., Jain, C., Bois, M. C., Behfar, A., Olivier, K., & Markovic, S. N. (2019). Heart Block Caused by Cardiac Metastasis From Merkel Cell Carcinoma: A Case Report. Mayo Clinic proceedings. Innovations, quality & outcomes, 3(4), 510-516. https://doi.org/10.1016/j.mayocpiqo.2019.09.005
Kazemi, Nazanin Yeganeh, et al. "Heart Block Caused by Cardiac Metastasis From Merkel Cell Carcinoma: A Case Report." Mayo Clinic proceedings. Innovations, quality & outcomes vol. 3,4 (2019): 510-516. doi: https://doi.org/10.1016/j.mayocpiqo.2019.09.005
Kazemi NY, Jain C, Bois MC, Behfar A, Olivier K, Markovic SN. Heart Block Caused by Cardiac Metastasis From Merkel Cell Carcinoma: A Case Report. Mayo Clin Proc Innov Qual Outcomes. 2019 Nov 22;3(4):510-516. doi: 10.1016/j.mayocpiqo.2019.09.005. eCollection 2019 Dec. PMID: 31993571; PMCID: PMC6978596.
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Mayo Clin Proc Innov Qual Outcomes. 2019 Nov 22;3(4):510-516. doi: 10.1016/j.mayocpiqo.2019.09.005. eCollection 2019 Dec.

Heart Block Caused by Cardiac Metastasis From Merkel Cell Carcinoma: A Case Report.

Mayo Clinic proceedings. Innovations, quality & outcomes

Nazanin Yeganeh Kazemi, Christopher Jain, Melanie C Bois, Atta Behfar, Kenneth Olivier, Svetomir N Markovic

Affiliations

  1. Medical Scientist Training Program, Mayo Clinic, Rochester, MN.
  2. Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
  3. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
  4. Department of Radiation Oncology, Mayo Clinic, Rochester, MN.
  5. Department of Oncology, Mayo Clinic, Rochester, MN.

PMID: 31993571 PMCID: PMC6978596 DOI: 10.1016/j.mayocpiqo.2019.09.005

Abstract

Merkel cell carcinoma (MCC) is a rare, rapidly proliferating skin cancer that commonly metastasizes to regional lymph nodes. We present the case of a 73-year-old woman with a history of MCC and non-Hodgkin B-cell lymphoma who presented with second-degree heart block (Mobitz type II) caused by an interatrial mass. Temporary pacing was required before biopsy, which revealed metastatic MCC. Treatment included permanent pacing, anti-programmed cell death ligand 1 immunotherapy, and radiation to the heart resulting in notable decrease in tumor size and normalized cardiac rhythm.

© 2019 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc.

Keywords: CM, cardiac metastases; CT, computed tomography; FDG, [18F]-fluorodeoxyglucose; MCC, Merkel cell carcinoma; MCPyV, Merkel cell polyomavirus; MRI, magnetic resonance imaging; PD-L1, programmed cell death ligand 1; PET, positron emission tomography

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