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Ware EB, Smith JA, Zhao W, et al. Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid. Mayo Clin Proc Innov Qual Outcomes. 2019;3(4):448-460doi: 10.1016/j.mayocpiqo.2019.08.007.
Ware, E. B., Smith, J. A., Zhao, W., Ganesvoort, R. T., Curhan, G. C., Pollak, M., Mount, D. B., Turner, S. T., Chen, G., Shah, R. J., Kardia, S. L. R., & Lieske, J. C. (2019). Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid. Mayo Clinic proceedings. Innovations, quality & outcomes, 3(4), 448-460. https://doi.org/10.1016/j.mayocpiqo.2019.08.007
Ware, Erin B, et al. "Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid." Mayo Clinic proceedings. Innovations, quality & outcomes vol. 3,4 (2019): 448-460. doi: https://doi.org/10.1016/j.mayocpiqo.2019.08.007
Ware EB, Smith JA, Zhao W, Ganesvoort RT, Curhan GC, Pollak M, Mount DB, Turner ST, Chen G, Shah RJ, Kardia SLR, Lieske JC. Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid. Mayo Clin Proc Innov Qual Outcomes. 2019 Nov 22;3(4):448-460. doi: 10.1016/j.mayocpiqo.2019.08.007. eCollection 2019 Dec. PMID: 31993563; PMCID: PMC6978610.
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Mayo Clin Proc Innov Qual Outcomes. 2019 Nov 22;3(4):448-460. doi: 10.1016/j.mayocpiqo.2019.08.007. eCollection 2019 Dec.

Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid.

Mayo Clinic proceedings. Innovations, quality & outcomes

Erin B Ware, Jennifer A Smith, Wei Zhao, Ron T Ganesvoort, Gary C Curhan, Martin Pollak, David B Mount, Stephen T Turner, Guotao Chen, Ronak Jagdeep Shah, Sharon L R Kardia, John C Lieske

Affiliations

  1. Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor.
  2. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor.
  3. Department of Internal Medicine, University of Groningen, Groningen, the Netherlands.
  4. Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
  5. Renal Division, Beth Israel Deaconess Medical Center, Boston, MA.
  6. Renal Division, Department of Medicine, VA Boston Healthcare System, Boston, MA.
  7. Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
  8. Department of Nephrology, The People's Hospital of Bishan District, Chongqing City, China.

PMID: 31993563 PMCID: PMC6978610 DOI: 10.1016/j.mayocpiqo.2019.08.007

Abstract

OBJECTIVES: The urinary excretion of organic and inorganic substances and their concentrations have attracted extensive attention for their role in the pathogenesis of urinary stone disease. The urinary excretion of specific factors associates with sex and age and seems to have a hereditary component, but the precise genomic determinants remain ill-defined.

METHODS: Genome-wide association studies previously conducted in 3 cohorts (Genetic Epidemiology Network of Arteriopathy study, January 1, 2006, through December 31, 2012; the combined Nurses' Health Study (NHS), NHS II, and Health Professionals Follow-up Study, January 1, 1994, through December 31, 2003; and the Prevention of Renal and Vascular End-stage Disease study, January 1, 1997, through December 31, 1998) were combined into meta-analyses to evaluate genetic associations with available urinary phenotypes relevant to stone pathogenesis (calcium, magnesium, and uric acid excretion; total urine volume).

RESULTS: One region on chromosome 9q21.13 showed strong evidence of an association with urinary magnesium excretion. The strongest signal in this region was near

CONCLUSION: Common variants near genes important for magnesium metabolism and bone health associate with urinary magnesium and calcium excretion.

© 2019 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc.

Keywords: BMI, body mass index; CKD, chronic kidney disease; FGF23, fibroblast growth factor 23; GDUL, Genetic Determinants of Urinary Lithogenicity; GENOA, Genetic Epidemiology Network of Arteriopathy; GWAS, Genome-wide association study; HPFS, Health Professionals Follow-up Study; NHS, Nurses’ Health Study; PREVEND, Prevention of Renal and Vascular End-stage Disease; QQ, quantile-quantile; SNP, single nucleotide polymorphism

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