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Mayo Clin Proc Innov Qual Outcomes. 2019 Oct 22;3(4):409-417. doi: 10.1016/j.mayocpiqo.2019.08.006. eCollection 2019 Dec.

Impact of Body Mass Index on the Association of Ankle-Brachial Index With All-Cause and Cardiovascular Mortality: Results from the National Health and Nutrition Examination Survey.

Mayo Clinic proceedings. Innovations, quality & outcomes

Mohammad-Ali Jazayeri, Salman Waheed, Zubair Shah, Deepak Parashara, Kamal Gupta

Affiliations

  1. Department of Cardiovascular Medicine, University of Kansas Medical Center, Kansas City, KS.
  2. Division of Cardiovascular Disease, University of Alabama Birmingham, AL.
  3. Division of Cardiovascular Disease, Kansas City Veterans Affairs Medical Center, MO.

PMID: 31993559 PMCID: PMC6978603 DOI: 10.1016/j.mayocpiqo.2019.08.006

Abstract

OBJECTIVE: To assess the influence of body-mass index (BMI) on the association of ankle-brachial index (ABI) with mortality.

PATIENTS AND METHODS: We conducted a prospective study of National Health and Nutrition Examination Survey participants enrolled from January 1, 1999 to December 31, 2002 with BMI and ABI data available. ABI categories were <0.9 (low), 0.9 to 1.3 (reference), and >1.3 (high). BMI categories were <30 kg/m

RESULTS: In total, 4614 subjects were included, with mean age 56±12 years and BMI 28±6 kg/m

CONCLUSION: In a US cohort, weight influenced the prognostic significance of high ABI. This may be related to technical factors reducing compressibility of the calf arteries in obese persons compared with those who are nonobese.

© 2019 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc.

Keywords: ABI, ankle-brachial index; BMI, body mass index; BP, blood pressure; CV, cardiovascular; LE, lower extremity; MAC, medial arterial calcification; NHANES, National Health and Nutrition Examination Survey

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