Display options
Cite
Basinger MA, Jones MM, Craft WD, et al. Chelating-agent suppression of cadmium-induced hepatotoxicity. J Toxicol Environ Health. 1987;22(3):261-71doi: 10.1080/15287398709531070.
Basinger, M. A., Jones, M. M., Craft, W. D., Walker, E. M., & Sanders, M. M. (1987). Chelating-agent suppression of cadmium-induced hepatotoxicity. Journal of toxicology and environmental health, 22(3), 261-71. https://doi.org/10.1080/15287398709531070
Basinger, M A, et al. "Chelating-agent suppression of cadmium-induced hepatotoxicity." Journal of toxicology and environmental health vol. 22,3 (1987): 261-71. doi: https://doi.org/10.1080/15287398709531070
Basinger MA, Jones MM, Craft WD, Walker EM, Sanders MM. Chelating-agent suppression of cadmium-induced hepatotoxicity. J Toxicol Environ Health. 1987;22(3):261-71. doi: 10.1080/15287398709531070. PMID: 2890768.
Copy Download .nbib Format: NLM
Share it on

J Toxicol Environ Health. 1987;22(3):261-71. doi: 10.1080/15287398709531070.

Chelating-agent suppression of cadmium-induced hepatotoxicity.

Journal of toxicology and environmental health

M A Basinger, M M Jones, W D Craft, E M Walker, M M Sanders

Affiliations

  1. Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235.

PMID: 2890768 DOI: 10.1080/15287398709531070

Abstract

The administration of sodium N-methyl-N-dithiocarboxy-D-glucamine (NaG) at 500 mg/kg, i.p., or sodium calcium diethylenetriaminepentaacetic acid (DTPA) at 632.5 mg/kg, i.p., reduces the serum enzyme levels characteristic of hepatic damage following the intravenous administration of cadmium chloride (3.5 mg CdCl2.2.5H2O/kg). Some effect on serum enzyme levels was found even when the interval between administration of cadmium chloride and that of the antagonist was as great as 4 h. The enzymes examined included aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), alanine aminotransferase (SGPT), and alkaline phosphatase (AP). A histopathological examination of the livers of such animals also reveals the presence of a significant protective action.

Similar articles

Substances

MeSH terms

Publication Types

Grant support

LinkOut - more resources