Display options
Cite
Ely DL, Friberg P, Nilsson H, et al. Blood pressure and heart rate responses to mental stress in spontaneously hypertensive (SHB) and normotensive (WKY) rats on various sodium diets. Acta Physiol Scand. 1985;123(2):159-69doi: 10.1111/j.1748-1716.1985.tb07573.x.
Ely, D. L., Friberg, P., Nilsson, H., & Folkow, B. (1985). Blood pressure and heart rate responses to mental stress in spontaneously hypertensive (SHB) and normotensive (WKY) rats on various sodium diets. Acta physiologica Scandinavica, 123(2), 159-69. https://doi.org/10.1111/j.1748-1716.1985.tb07573.x
Ely, D L, et al. "Blood pressure and heart rate responses to mental stress in spontaneously hypertensive (SHB) and normotensive (WKY) rats on various sodium diets." Acta physiologica Scandinavica vol. 123,2 (1985): 159-69. doi: https://doi.org/10.1111/j.1748-1716.1985.tb07573.x
Ely DL, Friberg P, Nilsson H, Folkow B. Blood pressure and heart rate responses to mental stress in spontaneously hypertensive (SHB) and normotensive (WKY) rats on various sodium diets. Acta Physiol Scand. 1985 Feb;123(2):159-69. doi: 10.1111/j.1748-1716.1985.tb07573.x. PMID: 2858959.
Copy Download .nbib Format: NLM
Share it on
Full text links
Wiley

Acta Physiol Scand. 1985 Feb;123(2):159-69. doi: 10.1111/j.1748-1716.1985.tb07573.x.

Blood pressure and heart rate responses to mental stress in spontaneously hypertensive (SHB) and normotensive (WKY) rats on various sodium diets.

Acta physiologica Scandinavica

D L Ely, P Friberg, H Nilsson, B Folkow

PMID: 2858959 DOI: 10.1111/j.1748-1716.1985.tb07573.x

Abstract

Normotensive (WKY) and hypertensive rats (SHR) were, from 5 to 12 weeks of age, given 'low' (LNa), 'control' and 'high' (HNa) Na diets (0.5, 5 and 50 mmol X 100 g-1 food, respectively, during weekly recordings of body weight, conscious indirect systolic blood pressure (SBP) and heart rate (HR). During the last week, mean arterial pressure (MAP) and HR responses to standardized stress stimuli (air jet) were recorded before and after sequential cardiac nerve blockade. While resting, SBP was about equal in all WKY groups, but it was significantly reduced in SHR-LNa (152 mmHg versus 174 and 178 mmHg in SHR controls and HNa; P less than 0.05). In both LNa groups HR was elevated nearly 25% compared with controls, being in SHR 513 versus 419 bpm (P less than 0.01) and in WKY 489 versus 393 bpm (P less than 0.01). Cardiac nerve blockade indicated that this HR elevation was about equally due to elevations of sympathetic activity and 'intrinsic' pacemaker activity. SHR-LNa also showed attenuated MAP elevations to acute mental stress. There were, however, no significant differences between groups concerning haematocrit or plasma Na-K levels. The results suggest that SHR have a greater salt requirement than WKY, as Na restriction to one-tenth of normal led to a considerable MAP reduction in SHR despite compensatory sympathetic activation, and also to attenuated pressor responses to mental stress. Further, the cardiovascular effects in SHR were much more extensive when on a low-Na diet than when Na intake was increased tenfold above normal.

Similar articles

Cited by

Substances

MeSH terms

Publication Types

LinkOut - more resources