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Dominici C, Negroni A, Romeo A, et al. Association of near-diploid DNA content and N-myc amplification in neuroblastomas. Clin Exp Metastasis. 1989;7(2):201-11doi: 10.1007/BF01787024.
Dominici, C., Negroni, A., Romeo, A., Castello, M. A., Clerico, A., Scopinaro, M., Mauro, F., & Raschellà, G. (1989). Association of near-diploid DNA content and N-myc amplification in neuroblastomas. Clinical & experimental metastasis, 7(2), 201-11. https://doi.org/10.1007/BF01787024
Dominici, C, et al. "Association of near-diploid DNA content and N-myc amplification in neuroblastomas." Clinical & experimental metastasis vol. 7,2 (1989): 201-11. doi: https://doi.org/10.1007/BF01787024
Dominici C, Negroni A, Romeo A, Castello MA, Clerico A, Scopinaro M, Mauro F, Raschellà G. Association of near-diploid DNA content and N-myc amplification in neuroblastomas. Clin Exp Metastasis. 1989 Mar-Apr;7(2):201-11. doi: 10.1007/BF01787024. PMID: 2920475.
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Clin Exp Metastasis. 1989 Mar-Apr;7(2):201-11. doi: 10.1007/BF01787024.

Association of near-diploid DNA content and N-myc amplification in neuroblastomas.

Clinical & experimental metastasis

C Dominici, A Negroni, A Romeo, M A Castello, A Clerico, M Scopinaro, F Mauro, G Raschellà

Affiliations

  1. Department of Pediatrics, University La Sapienza, Rome, Italy.

PMID: 2920475 DOI: 10.1007/BF01787024

Abstract

Seventeen neuroblastomas at different clinical stages were analysed for their N-myc copy number and flow cytometrically determined DNA content. Aneuploidy was found in 11 patients (65 per cent), whereas the remaining were near-diploid. N-myc amplification was found significantly (P less than 0.05) confined to near-diploid tumors (3 out of 6 cases). This finding indicates a very selective mechanism of oncogene amplification which is independent of gross chromosomal imbalance and limited to specific loci in the human genome. Association of near-diploidy and age at diagnosis older than 24 months was also demonstrated (P less than 0.05). Thus, flow cytometric analysis of DNA content together with N-myc gene dosage allowed us to distinguish two different subsets of neuroblastoma tumors: the first one aneuploid, with single-copy N-myc, usually observed in patients younger than 24 months with localized or IV-S clinical stages; the second one near-diploid, with frequent N-myc amplification, usually observed in patients older than 24 months with advanced clinical stages.

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