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Teixeira CJ, Veras K, de Oliveira Carvalho CR. Dehydroepiandrosterone on metabolism and the cardiovascular system in the postmenopausal period. J Mol Med (Berl). 2019;98(1):39-57doi: 10.1007/s00109-019-01842-5.
Teixeira, C. J., Veras, K., & de Oliveira Carvalho, C. R. (2020). Dehydroepiandrosterone on metabolism and the cardiovascular system in the postmenopausal period. Journal of molecular medicine (Berlin, Germany), 98(1), 39-57. https://doi.org/10.1007/s00109-019-01842-5
Teixeira, Caio Jordão, et al. "Dehydroepiandrosterone on metabolism and the cardiovascular system in the postmenopausal period." Journal of molecular medicine (Berlin, Germany) vol. 98,1 (2020): 39-57. doi: https://doi.org/10.1007/s00109-019-01842-5
Teixeira CJ, Veras K, de Oliveira Carvalho CR. Dehydroepiandrosterone on metabolism and the cardiovascular system in the postmenopausal period. J Mol Med (Berl). 2020 Jan;98(1):39-57. doi: 10.1007/s00109-019-01842-5. Epub 2019 Nov 12. PMID: 31713639.
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J Mol Med (Berl). 2020 Jan;98(1):39-57. doi: 10.1007/s00109-019-01842-5. Epub 2019 Nov 12.

Dehydroepiandrosterone on metabolism and the cardiovascular system in the postmenopausal period.

Journal of molecular medicine (Berlin, Germany)

Caio Jordão Teixeira, Katherine Veras, Carla Roberta de Oliveira Carvalho

Affiliations

  1. Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 105 Alexander Fleming St, Campinas, SP, 13083-881, Brazil.
  2. Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, 1524 Prof. Lineu Prestes Ave., ICB 1, Sao Paulo, SP, 05508-900, Brazil.
  3. Department of Nutrition, University of Mogi das Cruzes, 200 Dr. Cândido X. A. Souza Ave., Sao Paulo, SP, 08780-911, Brazil.
  4. Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, 1524 Prof. Lineu Prestes Ave., ICB 1, Sao Paulo, SP, 05508-900, Brazil. [email protected].

PMID: 31713639 DOI: 10.1007/s00109-019-01842-5

Abstract

Dehydroepiandrosterone (DHEA), mostly present as its sulfated ester (DHEA-S), is an anabolic hormone that naturally declines with age. Furthermore, it is the most abundant androgen and estrogen precursor in humans. Low plasma levels of DHEA have been strongly associated with obesity, insulin resistance, dyslipidemia, and high blood pressure, increasing the risk of cardiovascular disease. In this respect, DHEA could be regarded as a promising agent against metabolic syndrome (MetS) in postmenopausal women, since several age-related metabolic diseases are reported during aging. There are plenty of experimental evidences showing beneficial effects after DHEA therapy on carbohydrate and lipid metabolism, as well as cardiovascular health. However, its potential as a therapeutic agent appears to attract controversy, due to the lack of effects on some symptoms related to MetS. In this review, we examine the available literature regarding the impact of DHEA therapy on adiposity, glucose metabolism, and the cardiovascular system in the postmenopausal period. Both clinical studies and in vitro and in vivo experimental models were selected, and where possible, the main cellular mechanisms involved in DHEA therapy were discussed. Schematic representation showing some of the general effects observed after administration DHEA therapy on target tissues of energy metabolism and the cardiovascular system. ↑ represents an increase, ↓ represents a decrease, - represents a worsening and ↔ represents no change after DHEA therapy.

Keywords: Adiposity; Cardiovascular disease; Dehydroepiandrosterone; Insulin resistance; Menopause; Metabolic syndrome

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