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NPJ Breast Cancer. 2019 Nov 01;5:38. doi: 10.1038/s41523-019-0127-5. eCollection 2019.

The .

NPJ breast cancer

Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna I Kiiski, Taru A Muranen, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Goska Leslie, Cora M Aalfs, Muriel A Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A Agnarsson, Thomas Ahearn, Kristiina Aittomäki, Christine B Ambrosone, Lesley Andrews, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Norbert Arnold, Kristan J Aronson, Banu K Arun, Ella Asseryanis, Bernd Auber, Päivi Auvinen, Jacopo Azzollini, Judith Balmaña, Rosa B Barkardottir, Daniel Barrowdale, Julian Barwell, Laura E Beane Freeman, Charles Joly Beauparlant, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Raanan Berger, Marina Bermisheva, Amie M Blanco, Carl Blomqvist, Natalia V Bogdanova, Anders Bojesen, Stig E Bojesen, Bernardo Bonanni, Ake Borg, Angela F Brady, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Saundra S Buys, Trinidad Caldés, Almuth Caliebe, Maria A Caligo, Daniele Campa, Ian G Campbell, Federico Canzian, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Kathleen B M Claes, Christine L Clarke, Anita Collavoli, Thomas A Conner, David G Cox, Cezary Cybulski, Kamila Czene, Mary B Daly, Miguel de la Hoya, Peter Devilee, Orland Diez, Yuan Chun Ding, Gillian S Dite, Nina Ditsch, Susan M Domchek, Cecilia M Dorfling, Isabel Dos-Santos-Silva, Katarzyna Durda, Miriam Dwek, Diana M Eccles, Arif B Ekici, A Heather Eliassen, Carolina Ellberg, Mikael Eriksson, D Gareth Evans, Peter A Fasching, Jonine Figueroa, Henrik Flyger, William D Foulkes, Tara M Friebel, Eitan Friedman, Marike Gabrielson, Pragna Gaddam, Manuela Gago-Dominguez, Chi Gao, Susan M Gapstur, Judy Garber, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Simon A Gayther, Graham G Giles, Gord Glendon, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Pascal Guénel, Angelica M Gutierrez-Barrera, Lothar Haeberle, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia A Harrington, Alexander Hein, Jane Heyworth, Peter Hillemanns, Antoinette Hollestelle, John L Hopper, H Dean Hosgood, Anthony Howell, Chunling Hu, Peter J Hulick, David J Hunter, Evgeny N Imyanitov, Claudine Isaacs, Milena Jakimovska, Anna Jakubowska, Paul James, Ramunas Janavicius, Wolfgang Janni, Esther M John, Michael E Jones, Audrey Jung, Rudolf Kaaks, Beth Y Karlan, Elza Khusnutdinova, Cari M Kitahara, Irene Konstantopoulou, Stella Koutros, Peter Kraft, Diether Lambrechts, Conxi Lazaro, Loic Le Marchand, Jenny Lester, Fabienne Lesueur, Jenna Lilyquist, Jennifer T Loud, Karen H Lu, Robert N Luben, Jan Lubinski, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, John W M Martens, Tabea Maurer, Dimitrios Mavroudis, Noura Mebirouk, Alfons Meindl, Usha Menon, Austin Miller, Marco Montagna, Katherine L Nathanson, Susan L Neuhausen, William G Newman, Tu Nguyen-Dumont, Finn Cilius Nielsen, Sarah Nielsen, Liene Nikitina-Zake, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Andrew F Olshan, Janet E Olson, Håkan Olsson, Ana Osorio, Laura Ottini, Bernard Peissel, Ana Peixoto, Julian Peto, Dijana Plaseska-Karanfilska, Timea Pocza, Nadege Presneau, Miquel Angel Pujana, Kevin Punie, Brigitte Rack, Johanna Rantala, Muhammad U Rashid, Rohini Rau-Murthy, Gad Rennert, Flavio Lejbkowicz, Valerie Rhenius, Atocha Romero, Matti A Rookus, Eric A Ross, Maria Rossing, Vilius Rudaitis, Matthias Ruebner, Emmanouil Saloustros, Kristin Sanden, Marta Santamariña, Maren T Scheuner, Rita K Schmutzler, Michael Schneider, Christopher Scott, Leigha Senter, Mitul Shah, Priyanka Sharma, Xiao-Ou Shu, Jacques Simard, Christian F Singer, Christof Sohn, Penny Soucy, Melissa C Southey, John J Spinelli, Linda Steele, Dominique Stoppa-Lyonnet, William J Tapper, Manuel R Teixeira, Mary Beth Terry, Mads Thomassen, Jennifer Thompson, Darcy L Thull, Marc Tischkowitz, Rob A E M Tollenaar, Diana Torres, Melissa A Troester, Thérèse Truong, Nadine Tung, Michael Untch, Celine M Vachon, Elizabeth J van Rensburg, Elke M van Veen, Ana Vega, Alessandra Viel, Barbara Wappenschmidt, Jeffrey N Weitzel, Camilla Wendt, Greet Wieme, Alicja Wolk, Xiaohong R Yang, Wei Zheng, Argyrios Ziogas, Kristin K Zorn, Alison M Dunning, Michael Lush, Qin Wang, Lesley McGuffog, Michael T Parsons, Paul D P Pharoah, Florentia Fostira, Amanda E Toland, Irene L Andrulis, Susan J Ramus, Anthony J Swerdlow, Mark H Greene, Wendy K Chung, Roger L Milne, Georgia Chenevix-Trench, Thilo Dörk, Marjanka K Schmidt, Douglas F Easton, Paolo Radice, Eric Hahnen, Antonis C Antoniou, Fergus J Couch, Heli Nevanlinna, Jordi Surrallés, Paolo Peterlongo

Affiliations

  1. IFOM - the FIRC Institute for Molecular Oncology, Genome Diagnostics Program, Milan, Italy.
  2. 2Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona Spain.
  3. 3Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain.
  4. 4Institute of Biomedical Research, Sant Pau Hospital, Barcelona, Spain.
  5. Fondazione IRCCS Istituto Nazionale dei Tumori, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan, Italy.
  6. University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland.
  7. 7University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.
  8. The Cyprus Institute of Neurology & Genetics, Department of Electron Microscopy/Molecular Pathology and The Cyprus School of Molecular Medicine, Nicosia, Cyprus.
  9. 9Amsterdam UMC, lokatie AMC, Department of Clinical Genetics, Amsterdam, The Netherlands.
  10. The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Family Cancer Clinic, Amsterdam, The Netherlands.
  11. Chapel Allerton Hospital, Yorkshire Regional Genetics Service, Leeds, UK.
  12. Veneto Institute of Oncology IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy.
  13. Memorial Sloan-Kettering Cancer Center, Department of Medicine, New York, NY USA.
  14. Landspitali University Hospital, Department of Pathology, Reykjavik, Iceland.
  15. 15University of Iceland, School of Medicine, Reykjavik, Iceland.
  16. 16National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Bethesda, MD USA.
  17. 17University of Helsinki, Department of Clinical Genetics, Helsinki University Hospital, Helsinki, Finland.
  18. 18Roswell Park Cancer Institute, Buffalo, NY USA.
  19. Nelune Comprehensive Cancer Care Centre, The Bright Alliance Building, Randwick, NSW Australia.
  20. 20University of California Irvine, Department of Epidemiology, Genetic Epidemiology Research Institute, Irvine, CA USA.
  21. N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
  22. German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.
  23. University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Department of Gynaecology and Obstetrics, and Institute of Clinical Molecular Biology, Kiel, Germany.
  24. Queen's University, Department of Public Health Sciences, and Cancer Research Institute, Kingston, ON Canada.
  25. 25University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology, Houston, TX USA.
  26. 26Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria.
  27. 27Hannover Medical School, Institute of Human Genetics, Hannover, Germany.
  28. 28Kuopio University Hospital, Cancer Center, Kuopio, Finland.
  29. 29University of Eastern Finland, Institute of Clinical Medicine, Oncology, Kuopio, Finland.
  30. 30University of Eastern Finland, Translational Cancer Research Area, Kuopio, Finland.
  31. 31Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Department of Medical Oncology and Hematology, Unit of Medical Genetics, Milan, Italy.
  32. 32Vall d'Hebron Institute of Oncology, High Risk and Cancer Prevention Group, Barcelona, Spain.
  33. 33University Hospital, Vall d'Hebron, Department of Medical Oncology, Barcelona, Spain.
  34. 34University of Iceland, BMC (Biomedical Centre), Faculty of Medicine, Reykjavik, Iceland.
  35. 35University Hospitals of Leicester NHS Trust, Leicestershire Clinical Genetics Service, Leicester, UK.
  36. 36Centre Hospitalier Universitaire de Québec - Université Laval, Research Center, Genomics Center, Québec City, QC Canada.
  37. University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.
  38. German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
  39. Spanish National Cancer Research Centre (CNIO), Human Genetics Group, Human Cancer Genetics Programme, Madrid, Spain.
  40. 40Spanish Network on Rare Diseases (CIBERER), Madrid, Spain.
  41. 41Spanish National Cancer Research Centre (CNIO), Genotyping Unit (CEGEN), Human Cancer Genetics Programme, Madrid, Spain.
  42. Chaim Sheba Medical Center, The Institute of Oncology, Ramat Gan, Israel.
  43. 43Ufa Federal Research Center of the Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa, Russia.
  44. 44University of California San Francisco, Cancer Genetics and Prevention Program, San Francisco, CA USA.
  45. University of Helsinki, Department of Oncology, Helsinki University Hospital, Helsinki, Finland.
  46. 46Örebro University Hospital, Department of Oncology, Örebro, Sweden.
  47. Hannover Medical School, Department of Radiation Oncology, Hannover, Germany.
  48. Hannover Medical School, Gynaecology Research Unit, Hannover, Germany.
  49. 49Aarhus University Hospital, Department of Clinical Genetics, Aarhus, Denmark.
  50. Copenhagen University Hospital, Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev, Denmark.
  51. Copenhagen University Hospital, Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.
  52. 52University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
  53. 53IEO, European Institute of Oncology IRCCS, Division of Cancer Prevention and Genetics, Milan, Italy.
  54. 54Lund University and Skåne University Hospital, Department of Oncology, Lund, Sweden.
  55. 55London North West University Hospitals NHS Trust, Northwick Park Hospital, North West Thames Regional Genetics Service, Kennedy Galton Centre, Harrow, UK.
  56. 56Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
  57. 57University of Tübingen, iFIT-Cluster of Excellence, Tübingen, Germany.
  58. 58German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
  59. 59German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Division of Preventive Oncology, Heidelberg, Germany.
  60. 60Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany.
  61. 61German Cancer Research Center (DKFZ), Molecular Epidemiology Group, C080 Heidelberg, Germany.
  62. University of Heidelberg, Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, Heidelberg, Germany.
  63. 63Huntsman Cancer Institute, Department of Medicine, Salt Lake City, UT USA.
  64. 64Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Medical Oncology Department, Hospital Clínico San Carlos, Madrid, Spain.
  65. University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Institute of Human Genetics, Kiel, Germany.
  66. 66University Hospital of Pisa, Section of Molecular Genetics, Dept. of Laboratory Medicine, Pisa, Italy.
  67. 67University of Pisa, Department of Biology, Pisa, Italy.
  68. 68Peter MacCallum Cancer Center, Research Division, Melbourne, VIC Australia.
  69. 69The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC Australia.
  70. 70German Cancer Research Center (DKFZ), Genomic Epidemiology Group, Heidelberg, Germany.
  71. Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Oncology and Genetics Unit, Vigo, Spain.
  72. 72University Medical Center Hamburg-Eppendorf, Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), Hamburg, Germany.
  73. 73Ghent University, Centre for Medical Genetics, Gent, Belgium.
  74. 74University of Sydney, Westmead Institute for Medical Research, Sydney, NSW Australia.
  75. University and University Hospital of Pisa, Section of Genetic Oncology, Dept. of Laboratory Medicine, Pisa, Italy.
  76. 76Huntsman Cancer Institute, Salt Lake City, UT USA.
  77. 77Imperial College London, Department of Epidemiology and Biostatistics, School of Public Health, London, UK.
  78. 78Cancer Research Center of Lyon, INSERM, U1052 Lyon, France.
  79. 79Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland.
  80. 80Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.
  81. 81Fox Chase Cancer Center, Department of Clinical Genetics, Philadelphia, PA USA.
  82. 82Leiden University Medical Center, Department of Pathology, Leiden, The Netherlands.
  83. 83Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands.
  84. 84Vall d'Hebron Institute of Oncology (VHIO), Oncogenetics Group, Barcelona, Spain.
  85. 85University Hospital Vall d'Hebron, Area of Clinical and Molecular Genetics, Barcelona, Spain.
  86. 86Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA USA.
  87. 87The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, Victoria, Australia.
  88. 88Ludwig Maximilian University of Munich, Department of Gynecology and Obstetrics, Munich, Germany.
  89. Perelman School of Medicine at the University of Pennsylvania, Department of Medicine, Abramson Cancer Center, Philadelphia, PA USA.
  90. 90University of Pretoria, Department of Genetics, Arcadia, South Africa.
  91. 91London School of Hygiene and Tropical Medicine, Department of Non-Communicable Disease Epidemiology, London, UK.
  92. 92University of Westminster, Department of Biomedical Sciences, Faculty of Science and Technology, London, UK.
  93. 93University of Southampton, Cancer Sciences Academic Unit, Faculty of Medicine, Southampton, UK.
  94. Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Institute of Human Genetics, University Hospital Erlangen, Erlangen, Germany.
  95. 95Harvard Medical School, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA USA.
  96. 96Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA USA.
  97. 97Lund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden.
  98. 98University of Manchester, Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, UK.
  99. 99Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester Centre for Genomic Medicine, Manchester, UK.
  100. 100University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, Los Angeles, CA USA.
  101. 101The University of Edinburgh Medical School, Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK.
  102. Cancer Research UK Edinburgh Centre, Edinburgh, UK.
  103. Copenhagen University Hospital, Department of Breast Surgery, Herlev and Gentofte Hospital, Herlev, Denmark.
  104. 104McGill University, Program in Cancer Genetics, Departments of Human Genetics and Oncology, Montréal, QC Canada.
  105. 105Harvard T.H. Chan School of Public Health, Boston, MA USA.
  106. 106Dana-Farber Cancer Institute, Boston, MA USA.
  107. 107Chaim Sheba Medical Center, The Susanne Levy Gertner Oncogenetics Unit, Ramat Gan, Israel.
  108. 108Tel Aviv University, Sackler Faculty of Medicine, Ramat Aviv, Israel.
  109. 109Memorial Sloan-Kettering Cancer Center, Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, New York, NY USA.
  110. 110Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Genomic Medicine Group, Galician Foundation of Genomic Medicine, Santiago de Compostela, Spain.
  111. 111University of California San Diego, Moores Cancer Center, La Jolla, CA USA.
  112. 112Harvard T.H. Chan School of Public Health, Program in Genetic Epidemiology and Statistical Genetics, Boston, MA USA.
  113. 113American Cancer Society, Epidemiology Research Program, Atlanta, GA USA.
  114. Dana-Farber Cancer Institute, Cancer Risk and Prevention Clinic, Boston, MA USA.
  115. 116Cedars-Sinai Medical Center, The Center for Bioinformatics and Functional Genomics at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA USA.
  116. 117Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC Australia.
  117. 118Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, VIC Australia.
  118. 119Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON Canada.
  119. 120Kansas University Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, KS USA.
  120. 121McGill University, Department of Medicine, Montréal, QC Canada.
  121. 122McGill University, Division of Clinical Epidemiology, Royal Victoria Hospital, Montréal, QC Canada.
  122. 123Huntsman Cancer Institute, University of Utah School of Medicine, Department of Dermatology, Salt Lake City, UT USA.
  123. 124INSERM, University Paris-Sud, University Paris-Saclay, Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), Villejuif, France.
  124. 125University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology and Clinical Genetics Program, Houston, TX USA.
  125. 126Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Department of Gynaecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany.
  126. 127University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA USA.
  127. 128Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden.
  128. 129Södersjukhuset, Department of Oncology, Stockholm, Sweden.
  129. German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany.
  130. 131University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK.
  131. 132The University of Western Australia, School of Population and Global Health, Perth, WA Australia.
  132. 133Erasmus MC Cancer Institute, Department of Medical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands.
  133. 134Albert Einstein College of Medicine, Department of Epidemiology and Public Health, Bronx, NY USA.
  134. 135University of Manchester, Division of Cancer Sciences, Manchester, UK.
  135. 136Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN USA.
  136. 137NorthShore University HealthSystem, Center for Medical Genetics, Evanston, IL USA.
  137. 138The University of Chicago Pritzker School of Medicine, Chicago, IL USA.
  138. 139University of Oxford, Nuffield Department of Population Health, Oxford, UK.
  139. 140N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
  140. 141Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC USA.
  141. 142Macedonian Academy of Sciences and Arts, Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Skopje, Republic of Macedonia.
  142. 143Pomeranian Medical University, Independent Laboratory of Molecular Biology and Genetic Diagnostics, Szczecin, Poland.
  143. 144Peter MacCallum Cancer Center, Parkville Familial Cancer Centre, Melbourne, VIC Australia.
  144. 145Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius, Lithuania.
  145. State Research Institute Innovative Medicine Center, Vilnius, Lithuania.
  146. 147University Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm, Germany.
  147. 148Stanford University School of Medicine, Department of Medicine (Oncology) and Stanford Cancer Institute, Stanford, CA USA.
  148. 115The Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK.
  149. 149Cedars-Sinai Medical Center, Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA USA.
  150. 150Bashkir State Medical University, Department of Medical Genetics, Ufa, Russia.
  151. 151National Cancer Institute, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD USA.
  152. 152National Centre for Scientific Research 'Demokritos', Molecular Diagnostics Laboratory, INRASTES, Athens, Greece.
  153. 153VIB, VIB Center for Cancer Biology, Leuven, Belgium.
  154. 154University of Leuven, Laboratory for Translational Genetics, Department of Human Genetics, Leuven, Belgium.
  155. IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, CIBERONC, Molecular Diagnostic Unit, Hereditary Cancer Program, Barcelona, Spain.
  156. 156University of Hawaii Cancer Center, Epidemiology Program, Honolulu, HI USA.
  157. Inserm U900, Genetic Epidemiology of Cancer team, Paris, France.
  158. 158PSL University, Paris, France.
  159. 159Institut Curie, Paris, France.
  160. 160Mines ParisTech, Fontainebleau, France.
  161. 161Mayo Clinic, Department of Health Sciences Research, Rochester, MN USA.
  162. 162National Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD USA.
  163. 163University of Texas MD Anderson Cancer Center, Department of Gynecologic Oncology and Clinical Cancer Genetics Program, Houston, TX USA.
  164. 164University of Cambridge, Clinical Gerontology, Department of Public Health and Primary Care, Cambridge, UK.
  165. 165University of Eastern Finland, Institute of Clinical Medicine, Pathology and Forensic Medicine, Kuopio, Finland.
  166. 166Kuopio University Hospital, Imaging Center, Department of Clinical Pathology, Kuopio, Finland.
  167. Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden.
  168. 168University Hospital of Heraklion, Department of Medical Oncology, Heraklion, Greece.
  169. University College London, MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, London, UK.
  170. Roswell Park Cancer Institute, NRG Oncology, Clinical Trials Development Division, Buffalo, NY USA.
  171. 171Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC Australia.
  172. 199The University of Melbourne, Department of Clinical Pathology, Melbourne, VIC Australia.
  173. Rigshospitalet, Copenhagen University Hospital, Center for Genomic Medicine, Copenhagen, Denmark.
  174. The University of Chicago, Center for Clinical Cancer Genetics, Chicago, IL USA.
  175. 174Latvian Biomedical Research and Study Centre, Riga, Latvia.
  176. 175Memorial Sloan-Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY USA.
  177. 176National Institute of Oncology, Department of Molecular Genetics, Budapest, Hungary.
  178. 177University of North Carolina at Chapel Hill, Department of Epidemiology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC USA.
  179. 178University La Sapienza, Department of Molecular Medicine, Rome, Italy.
  180. 179Portuguese Oncology Institute, Department of Genetics, Porto, Portugal.
  181. IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, CIBERONC, ProCURE, Oncobell, Barcelona, Spain.
  182. 181Leuven Cancer Institute, University Hospitals Leuven, Multidisciplinary Breast Center, Department of General Medical Oncology, Leuven, Belgium.
  183. 182Karolinska Institutet, Clinical Genetics, Stockholm, Sweden.
  184. 183Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Department of Basic Sciences, Lahore, Pakistan.
  185. 184Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel.
  186. 185Hospital Universitario Puerta de Hierro, Medical Oncology Department, Madrid, Spain.
  187. 186The Netherlands Cancer Institute, Department of Epidemiology, Amsterdam, The Netherlands.
  188. 187Fox Chase Cancer Center, Biostatistics and Bioinformatics Facility, Philadelphia, PA USA.
  189. 188Vilnius University, Medical Faculty, Institute of Clinical Medicine, Vilnius, Lithuania.
  190. 189University Hospital of Larissa, Department of Oncology, Larissa, Greece.
  191. 190University of Wisconsin, Cancer Center at ProHealth Care, Waukesha, WI USA.
  192. 191Fundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain.
  193. 192Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago De Compostela, Spain.
  194. 193University Hospital of Cologne, Center for Hereditary Breast and Ovarian Cancer, Cologne, Germany.
  195. 194University of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.
  196. 195The Ohio State University, Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, Columbus, OH USA.
  197. 196University of Kansas Medical Center, Department of Internal Medicine, Division of Oncology, Westwood, KS USA.
  198. Vanderbilt University School of Medicine, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, TN USA.
  199. University of Heidelberg, National Center for Tumor Diseases, Heidelberg, Germany.
  200. BC Cancer, Population Oncology, Vancouver, BC Canada.
  201. 201University of British Columbia, School of Population and Public Health, Vancouver, BC Canada.
  202. 202Institut Curie, Service de Génétique, Paris, France.
  203. INSERM U830, Department of Tumour Biology, Paris, France.
  204. 204Université Paris Descartes, Paris, France.
  205. 205University of Southampton, Faculty of Medicine, Southampton, UK.
  206. 206University of Porto, Biomedical Sciences Institute (ICBAS), Porto, Portugal.
  207. 207Columbia University, Department of Epidemiology, Mailman School of Public Health, New York, NY USA.
  208. 208Odense University Hospital, Department of Clinical Genetics, Odence C, Denmark.
  209. Magee-Womens Hospital, University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA USA.
  210. 210University of Cambridge, Department of Medical Genetics, Cambridge, UK.
  211. 211Leiden University Medical Center, Department of Surgery, Leiden, The Netherlands.
  212. 212Pontificia Universidad Javeriana, Institute of Human Genetics, Bogota, Colombia.
  213. 213Beth Israel Deaconess Medical Center, Department of Medical Oncology, Boston, MA USA.
  214. Helios Clinics Berlin-Buch, Department of Gynecology and Obstetrics, Berlin, Germany.
  215. 215Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Division of Functional onco-genomics and genetics, Aviano, Italy.
  216. 216City of Hope, Clinical Cancer Genetics, Duarte, CA USA.
  217. 217Uppsala University, Department of Surgical Sciences, Uppsala, Sweden.
  218. Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA USA.
  219. 219QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD Australia.
  220. 220The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH USA.
  221. 221University of Toronto, Department of Molecular Genetics, Toronto, ON Canada.
  222. 222University of NSW Sydney, School of Women's and Children's Health, Faculty of Medicine, Sydney, NSW Australia.
  223. 223The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW Australia.
  224. The Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK.
  225. The Institute of Cancer Research, Division of Breast Cancer Research, London, UK.
  226. 226Columbia University, Departments of Pediatrics and Medicine, New York, NY USA.
  227. 227The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands.
  228. 228The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Division of Psychosocial Research and Epidemiology, Amsterdam, The Netherlands.
  229. 229Department of Genetics, Sant Pau Hospital, Barcelona, Spain.

PMID: 31700994 PMCID: PMC6825205 DOI: 10.1038/s41523-019-0127-5

Abstract

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes

© The Author(s) 2019.

Keywords: Cancer genetics

Conflict of interest statement

Competing interestsC.I. reports consulting with AstraZeneca and Pfizer and her institution receives research support for Tesaro, AstraZeneca, and Pfizer. B.Y.K. served on Invitae Corporation’s Advisor

References

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