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Int J Mol Sci. 2019 Oct 09;20(20). doi: 10.3390/ijms20204986.

Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis.

International journal of molecular sciences

Yu-Chin Liu, Chau-Ting Yeh, Kwang-Huei Lin

Affiliations

  1. Department of Biochemistry, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan. [email protected].
  2. Department of Biomedical Sciences, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan. [email protected].
  3. Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. [email protected].
  4. Department of Biochemistry, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan. [email protected].
  5. Department of Biomedical Sciences, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan. [email protected].
  6. Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. [email protected].
  7. Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. [email protected].

PMID: 31600974 PMCID: PMC6834155 DOI: 10.3390/ijms20204986

Abstract

Several physiological processes, including cellular growth, embryonic development, differentiation, metabolism and proliferation, are modulated by genomic and nongenomic actions of thyroid hormones (TH). Several intracellular and extracellular candidate proteins are regulated by THs. 3,3,5-Triiodo-L-thyronine (T

Keywords: 3,3,5-triiodo-L-thyronine (T3), L-thyroxine (T4), cancer proliferation; thyroid hormone; thyroid hormone receptor

References

  1. Mol Endocrinol. 2008 Jun;22(6):1357-69 - PubMed
  2. Ann Surg Oncol. 2010 Aug;17(8):2222-8 - PubMed
  3. J Mol Endocrinol. 2006 Feb;36(1):9-21 - PubMed
  4. J Pathol. 2000 Dec;192(4):460-9 - PubMed
  5. Cancer Lett. 1994 Jan 30;76(2-3):177-83 - PubMed
  6. Biochem Biophys Res Commun. 1997 Dec 8;241(1):132-5 - PubMed
  7. Cancer. 2005 Mar 15;103(6):1122-8 - PubMed
  8. Nat Rev Drug Discov. 2009 Apr;8(4):308-20 - PubMed
  9. Exp Cell Res. 1995 May;218(1):1-8 - PubMed
  10. Toxicology. 2016 Aug 10;368-369:69-79 - PubMed
  11. Oncogene. 2006 Jun 15;25(25):3576-88 - PubMed
  12. ISRN Endocrinol. 2014 Feb 20;2014:317398 - PubMed
  13. Carcinogenesis. 2008 Jan;29(1):62-9 - PubMed
  14. J Biol Chem. 2000 Jul 21;275(29):21785-8 - PubMed
  15. Cell. 2006 Nov 3;127(3):469-80 - PubMed
  16. Nat Commun. 2013;4:2531 - PubMed
  17. Am J Physiol Cell Physiol. 2009 May;296(5):C977-9 - PubMed
  18. PLoS One. 2011;6(6):e20861 - PubMed
  19. Biomed Res Int. 2013;2013:601361 - PubMed
  20. Science. 1999 Jun 25;284(5423):2174-7 - PubMed
  21. Br Med J. 1978 Jan 28;1(6107):210-2 - PubMed
  22. Gastroenterology. 2012 Oct;143(4):1037-47 - PubMed
  23. J Clin Invest. 2005 Aug;115(8):1972-83 - PubMed
  24. J Endocrinol Invest. 2005 Jul-Aug;28(7):657-62 - PubMed
  25. Discov Med. 2011 Apr;11(59):337-47 - PubMed
  26. Mol Biol Rep. 2011 Feb;38(2):1137-44 - PubMed
  27. Oncotarget. 2015 Jun 20;6(17):15050-64 - PubMed
  28. Mol Carcinog. 1999 Sep;26(1):53-61 - PubMed
  29. Steroids. 2007 Feb;72(2):180-7 - PubMed
  30. Front Endocrinol (Lausanne). 2015 Jan 12;5:240 - PubMed
  31. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8329-33 - PubMed
  32. Hepatology. 2012 Mar;55(3):910-20 - PubMed
  33. Gastroenterology. 2010 May;138(5):1863-74 - PubMed
  34. Circ Res. 2004 Jun 11;94(11):1500-6 - PubMed
  35. EMBO J. 1994 Sep 15;13(18):4241-50 - PubMed
  36. Genes Dev. 1993 Jul;7(7B):1411-22 - PubMed
  37. PLoS One. 2011;6(11):e27547 - PubMed
  38. Genes Dev. 1998 Mar 1;12(5):599-606 - PubMed
  39. Mol Endocrinol. 2007 May;21(5):1108-19 - PubMed
  40. Sci Rep. 2016 May 12;6:25183 - PubMed
  41. Nature. 1997 Jun 12;387(6634):733-6 - PubMed
  42. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4363-8 - PubMed
  43. Compr Physiol. 2015 Dec 15;6(1):353-62 - PubMed
  44. Annu Rev Pharmacol Toxicol. 2011;51:99-115 - PubMed
  45. Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):570-4 - PubMed
  46. Mol Endocrinol. 1998 Oct;12(10):1605-18 - PubMed
  47. Horm Cancer. 2014 Aug;5(4):240-6 - PubMed
  48. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11697-702 - PubMed
  49. Am J Physiol Cell Physiol. 2009 May;296(5):C980-91 - PubMed
  50. Cell. 1999 Nov 24;99(5):447-50 - PubMed
  51. Cancer Lett. 2002 Jan 25;175(2):121-7 - PubMed
  52. Arch Intern Med. 1981 Aug;141(9):1161-4 - PubMed
  53. Acta Gastroenterol Belg. 1999 Oct-Dec;62(4):393-402 - PubMed
  54. Am J Cancer Res. 2011;1(2):168-191 - PubMed
  55. Hepatology. 2009 May;49(5):1563-70 - PubMed
  56. Nat Clin Pract Endocrinol Metab. 2007 Sep;3(9):632-40 - PubMed
  57. J Biol Chem. 1990 Mar 25;265(9):5296-302 - PubMed
  58. Thromb Res. 2015 Jul;136(1):5-6 - PubMed
  59. Mol Cell Biol. 1998 Oct;18(10):6001-13 - PubMed
  60. Nat Clin Pract Endocrinol Metab. 2009 Jan;5(1):1 - PubMed
  61. Acta Med Austriaca. 1986;13(1):13-6 - PubMed
  62. Cell. 1996 May 3;85(3):403-14 - PubMed
  63. BMC Cancer. 2013 Jul 06;13:334 - PubMed
  64. Steroids. 2011 Aug;76(9):885-91 - PubMed
  65. Biochem Biophys Res Commun. 2013 Sep 13;439(1):60-5 - PubMed
  66. Am J Cancer Res. 2013 Jun 20;3(3):302-11 - PubMed
  67. Nat Rev Endocrinol. 2016 Feb;12(2):111-21 - PubMed
  68. Nature. 1995 Oct 5;377(6548):397-404 - PubMed
  69. J Pediatr Endocrinol Metab. 1997 Sep-Oct;10(5):535-8 - PubMed
  70. J Biol Chem. 1990 Jun 25;265(18):10514-21 - PubMed
  71. J Clin Endocrinol Metab. 1995 Jul;80(7):2033-40 - PubMed
  72. J Clin Invest. 1999 Jun;103(12):1617-8 - PubMed
  73. Thyroid. 2008 Feb;18(2):239-53 - PubMed
  74. Steroids. 2016 Jul;111:63-70 - PubMed
  75. J Cell Biochem. 2012 Jan;113(1):13-8 - PubMed
  76. J Clin Endocrinol Metab. 1989 Jan;68(1):208-14 - PubMed
  77. Oncologist. 2015 Jan;20(1):72-6 - PubMed
  78. Cell Cycle. 2009 Nov 1;8(21):3562-70 - PubMed
  79. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59 - PubMed
  80. Mol Cell Biol. 2006 Apr;26(8):3204-14 - PubMed
  81. J Neurosurg. 2013 Jun;118(6):1279-87 - PubMed
  82. Physiol Rev. 2001 Jul;81(3):1269-304 - PubMed
  83. Biochem Biophys Res Commun. 1996 Aug 23;225(3):1035-9 - PubMed
  84. Oncotarget. 2014 Dec 30;5(24):12891-907 - PubMed
  85. Genes Dev. 1999 Dec 15;13(24):3198-208 - PubMed
  86. J Clin Endocrinol Metab. 1992 Oct;75(4):1071-5 - PubMed
  87. Histol Histopathol. 2013 Feb;28(2):227-37 - PubMed
  88. Rev Endocr Metab Disord. 2000 Jan;1(1-2):9-18 - PubMed
  89. J Endocrinol Invest. 1983 Jun;6(3):217-23 - PubMed
  90. J Biol Chem. 1994 Apr 29;269(17):12704-9 - PubMed
  91. Mol Endocrinol. 1989 Feb;3(2):392-9 - PubMed
  92. Carcinogenesis. 2002 Jan;23(1):25-33 - PubMed
  93. Physiol Rev. 2001 Jul;81(3):1097-142 - PubMed
  94. Nutrients. 2017 Sep 21;9(10):null - PubMed
  95. J Biomed Sci. 2019 Mar 8;26(1):24 - PubMed
  96. Thyroid Res. 2011 Aug 03;4 Suppl 1:S9 - PubMed
  97. Cell. 1995 Dec 15;83(6):841-50 - PubMed
  98. J Steroid Biochem Mol Biol. 2008 Mar;109(1-2):57-66 - PubMed
  99. Cancer Res. 2006 Jul 15;66(14):7270-5 - PubMed
  100. Mol Carcinog. 2002 May;34(1):25-34 - PubMed
  101. Nucl Recept Signal. 2006;4:e020 - PubMed
  102. J Clin Endocrinol Metab. 2010 Apr;95(4):1972-80 - PubMed
  103. Science. 1995 Nov 24;270(5240):1354-7 - PubMed
  104. Mod Pathol. 2001 Nov;14(11):1126-32 - PubMed
  105. Tokushima J Exp Med. 1991 Jun;38(1-2):25-35 - PubMed
  106. Bull Exp Biol Med. 2013 Dec;156(2):245-7 - PubMed
  107. Oncol Rep. 2013 Oct;30(4):1651-60 - PubMed
  108. Gastroenterology. 2012 Feb;142(2):219-32 - PubMed
  109. Endocrinology. 1996 Oct;137(10):4073-81 - PubMed
  110. Science. 1980 Oct 17;210(4467):340-2 - PubMed
  111. Cancer Res. 2003 Sep 1;63(17):5274-80 - PubMed
  112. Proc Natl Acad Sci U S A. 1988 Aug;85(16):5804-8 - PubMed
  113. Oncogene. 2011 Jul 28;30(30):3381-90 - PubMed
  114. Nature. 1997 May 1;387(6628):43-8 - PubMed
  115. Endocrinology. 1992 Nov;131(5):2419-29 - PubMed
  116. Oncogene. 2004 Apr 29;23(20):3550-60 - PubMed
  117. Oncogene. 2013 Aug 15;32(33):3904-14 - PubMed
  118. Biochem J. 1999 Mar 1;338 ( Pt 2):427-32 - PubMed
  119. Endocr Rev. 2016 Apr;37(2):135-87 - PubMed
  120. Hum Pathol. 2004 Dec;35(12):1469-76 - PubMed
  121. Cell. 1997 May 2;89(3):373-80 - PubMed
  122. Genes Dev. 2000 May 1;14(9):1048-57 - PubMed
  123. Thyroid. 1997 Oct;7(5):775-8 - PubMed
  124. Endocr Rev. 2010 Apr;31(2):139-70 - PubMed
  125. Mol Endocrinol. 2008 Jan;22(1):47-55 - PubMed
  126. Front Physiol. 2015 Aug 21;6:237 - PubMed
  127. Mol Diagn. 2004;8(3):163-9 - PubMed
  128. Mol Endocrinol. 2005 Dec;19(12):2955-63 - PubMed
  129. Carcinogenesis. 2007 Dec;28(12):2451-8 - PubMed
  130. Expert Opin Investig Drugs. 2004 May;13(5):489-500 - PubMed
  131. Mol Cell Biol. 2000 Nov;20(22):8329-42 - PubMed
  132. Oncogene. 2002 Jan 24;21(5):761-8 - PubMed
  133. Mol Endocrinol. 2005 Jan;19(1):102-12 - PubMed
  134. Minerva Chir. 2010 Feb;65(1):59-69 - PubMed
  135. Thyroid. 2012 Sep;22(9):897-904 - PubMed
  136. Genes Dev. 1998 Nov 1;12(21):3357-68 - PubMed
  137. Sci Rep. 2017 Nov 28;7(1):16475 - PubMed
  138. Endocr Res Commun. 1975;2(4-5):309-25 - PubMed
  139. Cell. 1999 Nov 24;99(5):443-6 - PubMed
  140. Endocrinology. 2008 Aug;149(8):3817-31 - PubMed
  141. Steroids. 2011 Aug;76(9):829-33 - PubMed
  142. J Natl Cancer Inst. 2010 Apr 21;102(8):568-72 - PubMed
  143. Acta Endocrinol (Copenh). 1988 Jul;118(3):460-4 - PubMed
  144. Angiogenesis. 2014 Jul;17(3):463-9 - PubMed
  145. Gene. 2000 Mar 7;245(1):1-11 - PubMed
  146. J Clin Invest. 1989 Nov;84(5):1683-7 - PubMed
  147. PLoS One. 2015 Jun 01;10(6):e0127072 - PubMed
  148. Endocr J. 2006 Apr;53(2):181-7 - PubMed
  149. J Cell Physiol. 2012 Jun;227(6):2388-97 - PubMed
  150. J Endocrinol. 2014 Apr 22;221(2):R1-12 - PubMed
  151. J Endocrinol. 2017 Aug;234(2):R99-R121 - PubMed
  152. J Mol Endocrinol. 2008 Sep;41(3):177-86 - PubMed
  153. Mol Endocrinol. 2011 Jan;25(1):1-14 - PubMed
  154. Cancer Res. 1981 Aug;41(8):3040-5 - PubMed
  155. Bone. 2008 Sep;43(3):418-26 - PubMed
  156. Oncogene. 2012 Apr 19;31(16):2007-16 - PubMed
  157. Surg Neurol. 2008 Dec;70 Suppl 1:S1:4-8; discussion S1:8 - PubMed
  158. Oncotarget. 2017 Jan 31;8(5):8648-8656 - PubMed
  159. J Clin Invest. 1990 Jan;85(1):101-5 - PubMed
  160. Breast Cancer Res Treat. 2015 Jan;149(1):293-301 - PubMed
  161. Endocr Relat Cancer. 2013 Mar 22;20(2):R19-29 - PubMed
  162. Horm Cancer. 2015 Feb;6(1):7-12 - PubMed
  163. Mol Cell Biol. 2000 Apr;20(8):2718-26 - PubMed
  164. Int J Cancer. 1992 Apr 1;50(6):974-6 - PubMed
  165. Biochim Biophys Acta. 2013 Jul;1830(7):3908-16 - PubMed
  166. J Clin Endocrinol Metab. 1989 Aug;69(2):461-6 - PubMed
  167. Endocrinology. 1997 Dec;138(12):5308-15 - PubMed
  168. Endocr Regul. 2014 Apr;48(2):65-8 - PubMed
  169. Anticancer Res. 2018 May;38(5):2793-2802 - PubMed
  170. Braz J Med Biol Res. 2005 May;38(5):761-5 - PubMed
  171. J Clin Endocrinol Metab. 1980 Feb;50(2):223-5 - PubMed
  172. Endocrinology. 2004 Jul;145(7):3265-72 - PubMed
  173. Endocr Res. 2009;34(1-2):31-42 - PubMed
  174. Compr Physiol. 2016 Jun 13;6(3):1221-37 - PubMed
  175. Clin Endocrinol (Oxf). 1988 May;28(5):497-507 - PubMed
  176. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1959-64 - PubMed
  177. Endocrinology. 2005 Jul;146(7):2864-71 - PubMed

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