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Neurooncol Pract. 2017 Sep;4(3):161-170. doi: 10.1093/nop/npw028. Epub 2017 Feb 10.

Quality of survival and cognitive performance in children treated for medulloblastoma in the PNET 4 randomized controlled trial.

Neuro-oncology practice

Hugo Câmara-Costa, Kim S Bull, Colin Kennedy, Andreas Wiener, Gabriele Calaminus, Anika Resch, Virginie Kieffer, Clémence Lalande, Geraldina Poggi, Katja von Hoff, Jacques Grill, François Doz, Stefan Rutkowski, Maura Massimino, Rolf-Dieter Kortmann, Birgitta Lannering, Georges Dellatolas, Mathilde Chevignard,

Affiliations

  1. Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France (H.C.C., G.D.).
  2. University of Southampton, Faculty of Medicine, Southampton, SO16 6YD, UK (K.S.B., C.K.).
  3. University of Bonn, Paediatric Oncology, Bonn and University Hospital Muenster, Paediatric Oncology, Münster, Germany (A.W., G.C.).
  4. University Medical Center Hamburg-Eppendorf, Hamburg, Germany (A.R., K.V.H., S.R.).
  5. Hôpitaux de Saint Maurice, Saint Maurice; Groupe de Recherche Clinique Handicap Cognitif et Réadaptation; UPMC Paris 6, France (V.K.).
  6. Gustave Roussy, Villejuif 94805, France (C.L., J.G.).
  7. Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy (G.P.).
  8. Université Paris Saclay, Villejuif 94805, France (J.G.).
  9. Institut Curie and University Paris Descartes, Sorbonne Paris Cité, Paris, France (F.D.).
  10. Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy (M.M.).
  11. University of Leipzig, Department of Radiation Therapy, Leipzig, Germany (R.D.K.).
  12. University of Gothenburg, Department of Paediatric Oncology, Gothenburg, Sweden (B.L.).
  13. Saint Maurice Hospitals, Rehabilitation Department for children with acquired neurological injury; F-94410 Saint Maurice, France; Sorbonne Universités, UPMC Université Paris 06, INSERM, CNRS, LIB, F-7013 Paris, France (M.C.).

PMID: 31385949 PMCID: PMC6655414 DOI: 10.1093/nop/npw028

Abstract

BACKGROUND: The relationship between direct assessments of cognitive performance and questionnaires assessing quality of survival (QoS) is reported to be weak-to-nonexistent. Conversely, the associations between questionnaires evaluating distinct domains of QoS tend to be strong. This pattern remains understudied.

METHODS: In the HIT-SIOP PNET4 randomized controlled trial, cognitive assessments, including Full Scale, Verbal and Performance IQ, Working Memory, and Processing Speed, were undertaken in 137 survivors of standard-risk medulloblastoma from 4 European countries. QoS questionnaires, including self-reports and/or parent reports of the Behavior Rating Inventory of Executive Function (BRIEF), the Health Utilities Index, the Strengths and Difficulties Questionnaire, and the Pediatric Quality of Life Inventory, were completed for 151 survivors. Correlations among direct cognitive assessments, QoS questionnaires, and clinical data were examined in participants with both assessments available (n = 86).

RESULTS: Correlations between direct measures of cognitive performance and QoS questionnaires were weak, except for moderate correlations between the BRIEF Metacognition Index (parent report) and working memory (

CONCLUSIONS: We hypothesize that the strong correlations among QoS questionnaires is partially attributable to the positive/negative polarity of all questions on the questionnaires, coupled with the relative absence of disease-specific questions. These factors may be influenced by respondents' personality and emotional characteristics, unlike direct assessments of cognitive functioning, and should be taken into account in clinical trials.

Keywords: everyday executive functioning; intellectual ability; medulloblastoma; outcome; quality of survival

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