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Stucki F, Arnet B, Baumgartner C, et al. Isolated central nervous system relapse in acute lymphocytic leukemia (ALL) in children. Experiences of the Swiss Pediatric Oncology Group (SPOG/SAKK) 1976-1986. Helv Paediatr Acta. 1988;43(3):187-93
Stucki, F., Arnet, B., Baumgartner, C., Beck, D., Berchtold, W., Bertrand, A. M., Bleher, E. A., Caflisch, U., Delaleu, B., & Feldges, A. (1988). Isolated central nervous system relapse in acute lymphocytic leukemia (ALL) in children. Experiences of the Swiss Pediatric Oncology Group (SPOG/SAKK) 1976-1986. Helvetica paediatrica acta, 43(3), 187-93.
Stucki, F, et al. "Isolated central nervous system relapse in acute lymphocytic leukemia (ALL) in children. Experiences of the Swiss Pediatric Oncology Group (SPOG/SAKK) 1976-1986." Helvetica paediatrica acta vol. 43,3 (1988): 187-93.
Stucki F, Arnet B, Baumgartner C, Beck D, Berchtold W, Bertrand AM, Bleher EA, Caflisch U, Delaleu B, Feldges A. Isolated central nervous system relapse in acute lymphocytic leukemia (ALL) in children. Experiences of the Swiss Pediatric Oncology Group (SPOG/SAKK) 1976-1986. Helv Paediatr Acta. 1988 Nov;43(3):187-93. PMID: 3065299.
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Helv Paediatr Acta. 1988 Nov;43(3):187-93.

Isolated central nervous system relapse in acute lymphocytic leukemia (ALL) in children. Experiences of the Swiss Pediatric Oncology Group (SPOG/SAKK) 1976-1986.

Helvetica paediatrica acta

F Stucki, B Arnet, C Baumgartner, D Beck, W Berchtold, A M Bertrand, E A Bleher, U Caflisch, B Delaleu, A Feldges

Affiliations

  1. Institute for Clinical and Experimental Cancer Research, University of Berne, Switzerland.

PMID: 3065299

Abstract

The incidence of isolated CNS-relapse in the SPOG ALL studies 1976-1986 was analyzed and the prophylaxis of meningosis leucaemica of the different studies was compared. In the SPOG ALL high-risk study 1979-1983, the incidence of isolated CNS-relapse was significantly higher (17/71, 24%) than in the other studies. In this period, radiotherapy was omitted and the prophylactic treatment consisted only of moderately high doses of intravenous methotrexate and intrathecal methotrexate. In other studies, it was shown that the prophylactic combination of CNS-radiotherapy and intrathecal methotrexate, or the periodic administration of combined intrathecal chemotherapy alone, during the whole therapy of 2 1/2 years, produced comparably good results. The prophylaxis with the combined intrathecal chemotherapy was less neurotoxic and allowed the use of a curative radiotherapy in case of a CNS-relapse.

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