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Ruggieri M, Berini C, Ducasa N, et al. Molecular detection of human T-lymphotropic virus type 1 infection among oncology patients in Germany: A retrospective view. PLoS One. 2019;14(5):e0217560doi: 10.1371/journal.pone.0217560.
Ruggieri, M., Berini, C., Ducasa, N., Malkovsky, M., Fisch, P., & Biglione, M. (2019). Molecular detection of human T-lymphotropic virus type 1 infection among oncology patients in Germany: A retrospective view. PloS one, 14(5), e0217560. https://doi.org/10.1371/journal.pone.0217560
Ruggieri, Matias, et al. "Molecular detection of human T-lymphotropic virus type 1 infection among oncology patients in Germany: A retrospective view." PloS one vol. 14,5 (2019): e0217560. doi: https://doi.org/10.1371/journal.pone.0217560
Ruggieri M, Berini C, Ducasa N, Malkovsky M, Fisch P, Biglione M. Molecular detection of human T-lymphotropic virus type 1 infection among oncology patients in Germany: A retrospective view. PLoS One. 2019 May 28;14(5):e0217560. doi: 10.1371/journal.pone.0217560. eCollection 2019. PMID: 31136642; PMCID: PMC6538170.
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PLoS One. 2019 May 28;14(5):e0217560. doi: 10.1371/journal.pone.0217560. eCollection 2019.

Molecular detection of human T-lymphotropic virus type 1 infection among oncology patients in Germany: A retrospective view.

PloS one

Matias Ruggieri, Carolina Berini, Nicolas Ducasa, Miroslav Malkovsky, Paul Fisch, Mirna Biglione

Affiliations

  1. Institut für Klinische Pathologie, Universitätsklinikum Freiburg, Freiburg, Germany.
  2. Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.
  3. UW School of Medicine and Public Health, Madison, Wisconsin, United States of America.

PMID: 31136642 PMCID: PMC6538170 DOI: 10.1371/journal.pone.0217560

Abstract

Human T-cell lymphotropic virus (HTLV) belongs to a larger group of primate T-cell lymphotropic viruses (PTLVs) within the family Retroviridae. It is estimated that 10 to 20 million people worldwide may be infected with HTLV-1. Although most of them are asymptomatic, around 5% of infected individuals may develop either HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) or Adult T-cell Leukaemia/Lymphoma (ATLL). Public Health authorities in many countries have implemented routine blood-donor tests for HTLV-specific antibodies; but this is not the case for Germany since the reported prevalence is very low (7/100,000). With the aim to evaluate retrospectively the presence of HTLV-1 among oncology patients in this country, samples stored at the Universitätsklinikum Freiburg, were analyzed. For this purpose, two different nested-PCR (n-PCR) protocols have been modified and set up for HTLV-1 detection. One positive case was detected by n-PCR among 406 samples (0,25%) in a period of 5 years (2008-2012) corresponding to a T-Cell Lymphoma. Despite the low prevalence, this virus is circulating in Germany, probably due to the increasing numbers of immigrants in these last years. Physicians should consider HTLV-1 infection and suspect it taking in account the ethnic and relation to endemic regions regardless the patient's residence.

Conflict of interest statement

The authors have declared that no competing interests exist.

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