Horm Res. 1985;22(4):276-83. doi: 10.1159/000180106.

Some properties of the plasma hGH activity in patients with Laron-type dwarfism determined by a radioreceptor assay using human liver tissue.

Hormone research

R Eshet, S Peleg, Z Josefsberg, C Fuchs, R Arnon, Z Laron

PMID: 3000911 DOI: 10.1159/000180106

Abstract

A radioreceptor assay for human growth hormone (hGH) using the 100,000-g pellet of human liver tissue homogenates obtained from a 13-year-old male donor of a kidney transplantation is described. The dilution curves of the plasma hGH of 6 patients with Laron-type dwarfism (LTD) as well as those of the plasma hGH from 1 normal child and 2 acromegalic patients were all found to be parallel to the standard curve, suggesting that in the LTD syndrome the circulating hGH is biologically active.

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Substances

• Iodine Radioisotopes
• Receptors, Cell Surface
• Growth Hormone

MeSH terms

• Acromegaly / blood
• Adolescent
• Adult
• Dwarfism, Pituitary / blood
• Female
• Growth Hormone / blood
• Humans
• Iodine Radioisotopes
• Liver / metabolism
• Male
• Microsomes, Liver / metabolism
• Middle Aged
• Radioimmunoassay
• Radioligand Assay
• Receptors, Cell Surface / metabolism

Publication Types

• Journal Article

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