Display options
Cite
Hooper JS, Stanford KR, Alencar PA, et al. Nociceptive pulmonary-cardiac reflexes are altered in the spontaneously hypertensive rat. J Physiol. 2019;597(13):3255-3279doi: 10.1113/JP278085.
Hooper, J. S., Stanford, K. R., Alencar, P. A., Alves, N. G., Breslin, J. W., Dean, J. B., Morris, K. F., & Taylor-Clark, T. E. (2019). Nociceptive pulmonary-cardiac reflexes are altered in the spontaneously hypertensive rat. The Journal of physiology, 597(13), 3255-3279. https://doi.org/10.1113/JP278085
Hooper, J Shane, et al. "Nociceptive pulmonary-cardiac reflexes are altered in the spontaneously hypertensive rat." The Journal of physiology vol. 597,13 (2019): 3255-3279. doi: https://doi.org/10.1113/JP278085
Hooper JS, Stanford KR, Alencar PA, Alves NG, Breslin JW, Dean JB, Morris KF, Taylor-Clark TE. Nociceptive pulmonary-cardiac reflexes are altered in the spontaneously hypertensive rat. J Physiol. 2019 Jul;597(13):3255-3279. doi: 10.1113/JP278085. Epub 2019 May 30. PMID: 31077371; PMCID: PMC6602842.
Copy Download .nbib Format: NLM
Share it on

J Physiol. 2019 Jul;597(13):3255-3279. doi: 10.1113/JP278085. Epub 2019 May 30.

Nociceptive pulmonary-cardiac reflexes are altered in the spontaneously hypertensive rat.

The Journal of physiology

J Shane Hooper, Katherine R Stanford, Pierina A Alencar, Natascha G Alves, Jerome W Breslin, Jay B Dean, Kendall F Morris, Thomas E Taylor-Clark

Affiliations

  1. Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

PMID: 31077371 PMCID: PMC6602842 DOI: 10.1113/JP278085

Abstract

KEY POINTS: We investigated the cardiovascular and respiratory responses of the normotensive Wistar-Kyoto (WKY) rat and the spontaneously hypertensive (SH) rat to inhalation and intravenous injection of the noxious stimuli allyl isothiocyanate (AITC). AITC inhalation evoked atropine-sensitive bradycardia in conscious WKY rats, and evoked atropine-sensitive bradycardia and atenolol-sensitive tachycardia with premature ventricular contractions (PVCs) in conscious SH rats. Intravenous injection of AITC evoked bradycardia but no tachycardia/PVCs in conscious SHs, while inhalation and injection of AITC caused similar bradypnoea in conscious SH and WKY rats. Anaesthesia (inhaled isoflurane) inhibited the cardiac reflexes evoked by inhaled AITC but not injected AITC. Data indicate the presence of a de novo nociceptive pulmonary-cardiac reflex triggering sympathoexcitation in SH rats, and this reflex is dependent on vagal afferents but is not due to steady state blood pressure or due to remodelling of vagal efferent function.

ABSTRACT: Inhalation of noxious irritants/pollutants activates airway nociceptive afferents resulting in reflex bradycardia in healthy animals. Nevertheless, noxious pollutants evoke sympathoexcitation (tachycardia, hypertension) in cardiovascular disease patients. We hypothesize that cardiovascular disease alters nociceptive pulmonary-cardiac reflexes. Here, we studied reflex responses to irritants in normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive (SH) rats. Inhaled allyl isothiocyanate (AITC) evoked atropine-sensitive bradycardia with atrial-ventricular (AV) block in conscious WKY rats, thus indicating a parasympathetic reflex. Conversely, inhaled AITC in conscious SH rats evoked complex brady-tachycardia with both AV block and premature ventricular contractions (PVCs). Atropine abolished the bradycardia and AV block, but the atropine-insensitive tachycardia and PVCs were abolished by the β

© 2019 The Authors. The Journal of Physiology © 2019 The Physiological Society.

Keywords: ECG; TRPA1; airway afferents; airways; cardiovascular; reflex

References

  1. Nature. 1976 Dec 2;264(5585):454-6 - PubMed
  2. Eur Heart J. 1999 Dec;20(23):1752-6 - PubMed
  3. Epidemiology. 2000 Jan;11(1):11-7 - PubMed
  4. Toxicol Sci. 2000 Feb;53(2):430-7 - PubMed
  5. Science. 2000 Apr 14;288(5464):306-13 - PubMed
  6. Am J Respir Crit Care Med. 2000 Jun;161(6):1985-90 - PubMed
  7. Respir Physiol. 2001 Sep;127(2-3):113-24 - PubMed
  8. Toxicol Sci. 2002 Apr;66(2):327-35 - PubMed
  9. Eur Respir J Suppl. 2003 May;40:76s-80s - PubMed
  10. J Physiol. 1964 Mar;170:272-85 - PubMed
  11. J Appl Physiol (1985). 2003 Dec;95(6):2591-7 - PubMed
  12. Circulation. 2004 Jan 6;109(1):71-7 - PubMed
  13. Nature. 2004 Jan 15;427(6971):260-5 - PubMed
  14. Cardiovasc Toxicol. 2003;3(4):353-61 - PubMed
  15. Inhal Toxicol. 2004 Jun;16(6-7):421-9 - PubMed
  16. Clin Exp Pharmacol Physiol. 1992 Aug;19(8):587-97 - PubMed
  17. J Appl Physiol (1985). 1992 Mar;72(3):1050-6 - PubMed
  18. Environ Health Perspect. 2005 Mar;113(3):304-9 - PubMed
  19. Am J Physiol. 1992 May;262(5 Pt 2):R738-45 - PubMed
  20. Heart. 2006 Feb;92(2):220-7 - PubMed
  21. Hypertension. 1992 Jun;19(6 Pt 2):653-7 - PubMed
  22. Environ Health Perspect. 2005 Jul;113(7):883-7 - PubMed
  23. J Occup Health. 2005 Nov;47(6):471-80 - PubMed
  24. Cell. 2006 Mar 24;124(6):1269-82 - PubMed
  25. J Appl Physiol (1985). 2006 Aug;101(2):618-27 - PubMed
  26. Hypertension. 2006 Sep;48(3):443-52 - PubMed
  27. Arch Toxicol. 2007 Apr;81(4):299-307 - PubMed
  28. J Cardiovasc Pharmacol. 1990;16 Suppl 4:S60-4 - PubMed
  29. Circulation. 2006 Dec 5;114(23):2443-8 - PubMed
  30. Inhal Toxicol. 2007 Jan;19(1):1-12 - PubMed
  31. Clin Exp Pharmacol Physiol. 2006 Dec;33(12):1245-50 - PubMed
  32. J Occup Environ Med. 2007 Jun;49(6):610-7 - PubMed
  33. Cardiovasc Toxicol. 2007;7(1):28-51 - PubMed
  34. J Auton Nerv Syst. 1991 Dec;36(3):237-50 - PubMed
  35. J Neurosci. 2007 Oct 17;27(42):11412-5 - PubMed
  36. Environ Health Perspect. 2007 Nov;115(11):1617-22 - PubMed
  37. Toxicol Sci. 2008 Apr;102(2):328-36 - PubMed
  38. J Physiol. 2008 Mar 15;586(6):1595-604 - PubMed
  39. Environ Res. 2008 Jun;107(2):178-84 - PubMed
  40. J Physiol. 2008 Jul 15;586(14):3447-59 - PubMed
  41. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1429-38 - PubMed
  42. Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L858-65 - PubMed
  43. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1572-84 - PubMed
  44. J Physiol. 2008 Dec 1;586(23):5771-86 - PubMed
  45. FASEB J. 2009 Apr;23(4):1102-14 - PubMed
  46. Am J Respir Cell Mol Biol. 2009 Jun;40(6):756-62 - PubMed
  47. Hypertension. 1991 Aug;18(2):230-5 - PubMed
  48. J Physiol. 2010 Feb 1;588(Pt 3):423-33 - PubMed
  49. Stroke. 2010 Apr;41(4):588-93 - PubMed
  50. Acta Physiol (Oxf). 2010 Sep;200(1):87-95 - PubMed
  51. Circulation. 2010 Jun 1;121(21):2331-78 - PubMed
  52. J Physiol. 2010 Dec 1;588(Pt 23):4769-83 - PubMed
  53. Am J Physiol Lung Cell Mol Physiol. 2011 May;300(5):L790-8 - PubMed
  54. Environ Health Perspect. 2011 Jul;119(7):951-7 - PubMed
  55. Chem Res Toxicol. 2011 Jun 20;24(6):950-9 - PubMed
  56. J Hypertens. 1990 Mar;8(3):269-75 - PubMed
  57. J Physiol. 1990 Jul;426:355-68 - PubMed
  58. Am J Physiol Lung Cell Mol Physiol. 2012 May 1;302(9):L941-8 - PubMed
  59. Eur J Pharmacol. 2012 Aug 15;689(1-3):211-8 - PubMed
  60. PLoS One. 2014 Jan 23;9(1):e86868 - PubMed
  61. Circ Res. 2014 Mar 14;114(6):1004-21 - PubMed
  62. Hypertension. 2014 Jun;63(6):1309-18 - PubMed
  63. Part Fibre Toxicol. 2014 May 22;11:25 - PubMed
  64. Hypertension. 2014 Oct;64(4):745-55 - PubMed
  65. Pharmacol Rev. 2015;67(1):36-73 - PubMed
  66. J Appl Physiol (1985). 2015 Feb 1;118(3):273-81 - PubMed
  67. Clin Cardiol. 2015 Apr;38(4):251-8 - PubMed
  68. J Appl Physiol (1985). 1989 May;66(5):2032-8 - PubMed
  69. BMJ. 2015 Mar 24;350:h1295 - PubMed
  70. J Physiol. 2015 Jun 15;593(12):2547-9 - PubMed
  71. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 1;309(11):R1309-25 - PubMed
  72. J Appl Physiol (1985). 2016 Mar 15;120(6):580-91 - PubMed
  73. J Physiol. 2016 Oct 15;594(20):5975-5989 - PubMed
  74. Physiol Rev. 2016 Jul;96(3):975-1024 - PubMed
  75. Front Physiol. 2016 Jun 02;7:205 - PubMed
  76. Toxicol Appl Pharmacol. 2017 Jun 1;324:51-60 - PubMed
  77. J Appl Physiol (1985). 1989 Oct;67(4):1428-37 - PubMed
  78. Jpn Heart J. 1986 Jul;27(4):511-21 - PubMed
  79. J Appl Physiol (1985). 1987 Oct;63(4):1366-73 - PubMed
  80. Am J Physiol. 1987 Feb;252(2 Pt 2):R394-7 - PubMed
  81. Aust J Exp Biol Med Sci. 1973 Feb;51(1):17-31 - PubMed
  82. Circulation. 1973 May;47(5):959-66 - PubMed
  83. Rev Physiol Biochem Pharmacol. 1984;99:1-110 - PubMed
  84. Hypertension. 1980 Mar-Apr;2(2):119-24 - PubMed
  85. Circulation. 1981 Jan;63(1):1-10 - PubMed
  86. J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr;52(4):984-90 - PubMed
  87. Circ Res. 1982 Oct;51(4):525-31 - PubMed
  88. J Appl Physiol Respir Environ Exerc Physiol. 1982 Oct;53(4):985-91 - PubMed
  89. Circ Res. 1980 Dec;47(6):821-8 - PubMed
  90. Circ Res. 1980 Dec;47(6):829-34 - PubMed
  91. J Appl Physiol (1985). 1994 May;76(5):1848-55 - PubMed
  92. J Physiol. 1993 May;464:681-98 - PubMed
  93. J Pharmacol Exp Ther. 1993 Jan;264(1):509-14 - PubMed
  94. J Appl Physiol (1985). 1995 Nov;79(5):1679-86 - PubMed
  95. Respir Physiol. 1977 Apr;29(2):125-42 - PubMed
  96. Nat Med. 1996 Jul;2(7):814-7 - PubMed
  97. Respir Physiol. 1996 Jul;104(2-3):231-9 - PubMed
  98. Nature. 1996 Nov 28;384(6607):360-4 - PubMed
  99. Circulation. 1996 Dec 1;94(11):2850-5 - PubMed
  100. Nature. 1997 Oct 23;389(6653):816-24 - PubMed
  101. J Appl Physiol (1985). 1998 Feb;84(2):417-24 - PubMed
  102. Toxicol Sci. 1998 Feb;41(2):209-16 - PubMed

Substances

MeSH terms

Publication Types

Grant support