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Sung KC, Lee MY, Lee JY, et al. Utility of ALT Concentration in Men and Women with Nonalcoholic Fatty Liver Disease: Cohort Study. J Clin Med. 2019;8(4)doi: 10.3390/jcm8040445.
Sung, K. C., Lee, M. Y., Lee, J. Y., Lee, S. H., Kim, S. H., & Kim, S. H. (2019). Utility of ALT Concentration in Men and Women with Nonalcoholic Fatty Liver Disease: Cohort Study. Journal of clinical medicine, 8(4), . https://doi.org/10.3390/jcm8040445
Sung, Ki-Chul, et al. "Utility of ALT Concentration in Men and Women with Nonalcoholic Fatty Liver Disease: Cohort Study." Journal of clinical medicine vol. 8,4 (2019). doi: https://doi.org/10.3390/jcm8040445
Sung KC, Lee MY, Lee JY, Lee SH, Kim SH, Kim SH. Utility of ALT Concentration in Men and Women with Nonalcoholic Fatty Liver Disease: Cohort Study. J Clin Med. 2019 Apr 02;8(4). doi: 10.3390/jcm8040445. PMID: 30987010; PMCID: PMC6517922.
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J Clin Med. 2019 Apr 02;8(4). doi: 10.3390/jcm8040445.

Utility of ALT Concentration in Men and Women with Nonalcoholic Fatty Liver Disease: Cohort Study.

Journal of clinical medicine

Ki-Chul Sung, Mi-Yeon Lee, Jong-Young Lee, Sung-Ho Lee, Seong-Hwan Kim, Sun H Kim

Affiliations

  1. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea. [email protected].
  2. Division of Biostatistics, Department of R & D Management, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea. [email protected].
  3. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea. [email protected].
  4. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea. [email protected].
  5. Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. [email protected].
  6. Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. [email protected].
  7. Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA. [email protected].

PMID: 30987010 PMCID: PMC6517922 DOI: 10.3390/jcm8040445

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated alanine aminotransferase (ALT), but the clinical utility of ALT in detecting and following individuals with NAFLD remains unclear. We conducted a retrospective analysis of 30,988 men and 5204 women with NAFLD diagnosed by ultrasound and stratified them according to sex-specific ALT quartiles. We compared metabolic variables at baseline and repeated ultrasound after at least 6 months among ALT quartiles (Q) in men (Q1 5-24, Q2 25-33, Q3 34-48, Q4 ≥ 49 IU/L) and women (Q1 5-14, Q2 15-20, Q3 21-28, Q4 ≥ 29 IU/L). Prevalence of obesity (BMI ≥ 25 kg/m²) and metabolic abnormalities (glucose intolerance, hypertension) significantly (

Keywords: alanine transaminase; fatty liver; insulin resistance; non-alcoholic fatty liver disease; obesity

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