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Thomas KD, Greer DM, Couch MW, et al. Radiation dosimetry of iodine-123 HEAT, an alpha-1 receptor imaging agent. J Nucl Med. 1987;28(11):1745-50
Thomas, K. D., Greer, D. M., Couch, M. W., & Williams, C. M. (1987). Radiation dosimetry of iodine-123 HEAT, an alpha-1 receptor imaging agent. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 28(11), 1745-50.
Thomas, K D, et al. "Radiation dosimetry of iodine-123 HEAT, an alpha-1 receptor imaging agent." Journal of nuclear medicine : official publication, Society of Nuclear Medicine vol. 28,11 (1987): 1745-50.
Thomas KD, Greer DM, Couch MW, Williams CM. Radiation dosimetry of iodine-123 HEAT, an alpha-1 receptor imaging agent. J Nucl Med. 1987 Nov;28(11):1745-50. PMID: 2822868.
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J Nucl Med. 1987 Nov;28(11):1745-50.

Radiation dosimetry of iodine-123 HEAT, an alpha-1 receptor imaging agent.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

K D Thomas, D M Greer, M W Couch, C M Williams

Affiliations

  1. Veterans Administration Medical Center, Gainesville, Florida 32602.

PMID: 2822868
Free Article

Abstract

Biologic distribution data in the rat were obtained for the alpha-1 adrenoceptor imaging agent (+/-) 2-[beta-(iodo-4-hydroxyphenyl)ethylaminomethyl]tetralone (HEAT) labeled with [125I]. The major excretory routes were through the liver (67%) and the kidney (33%). Internal radiation absorbed dose estimates to nine source organs, total body, the GI tract, gonads, and red bone marrow were calculated for the human using the physical decay data for [123I]. The critical organ was found to be the lower large intestine, receiving 1.1 rad per mCi of [123I]HEAT administered. The total-body dose was found to be 58 mrad per mCi.

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