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Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 Jan;50(1):27-33.

[Effect of Guben Zenggu Decoction on Expressions of Serum BALP and .

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

[Article in Chinese]
Wan-Tao Dong, Kai Huang, Min Song, Ling-Tong Zhou, Hong-Yan Hou, Tao Liu, Yan-Long Gong, Xiao-Yu Liu, Lin-Bo Jiang

Affiliations

  1. Department of Joint Surgery, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730020, China.
  2. Clinical College of Traditonal Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.

PMID: 31037901

Abstract

OBJECTIVE: To observe the effect of Guben Zenggu Decoction on the expressions of calmodulin (

METHODS: The osteoporosis model was established by ovariectomy and randomly divided into model control group, Estradiol valerate group, Guben Zenggu Decoction high, medium and low concentration group. Selected the same age rats as the blank control group, after intervention, 10 rats were randomly selected at the time of 4th, 8th, 12th and 16th weeks from each group, After the success of the model and the successful intervention of Guben Zenggu Decoction for 4, 8, 12 and 16 weeks, the blood were taken from the heart, the serum bone alkaline phosphatase (BALP) levels was measured by the enzyme-linked immunosorbent assay (ELISA), and the thalamus, pituitary, spleen, adrenal, femoral tissue of rats were collected to detected the expressions of

RESULTS: At different time points (4 weeks, 8 weeks, 12 weeks, 16 weeks), the expressions of serum BALP and

CONCLUSION: Guben Zenggu Decoction can increase the serum concentration of BALP, regulate the expression of

Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).

Keywords: BALP ; CaM mRNA ; CaMKⅡ mRNA ; Guben Zenggu Decoction ; NEI network

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