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Levesque LA, Herzog AG, Seibel MM. The effect of phenytoin and carbamazepine on serum dehydroepiandrosterone sulfate in men and women who have partial seizures with temporal lobe involvement. J Clin Endocrinol Metab. 1986;63(1):243-5doi: 10.1210/jcem-63-1-243.
Levesque, L. A., Herzog, A. G., & Seibel, M. M. (1986). The effect of phenytoin and carbamazepine on serum dehydroepiandrosterone sulfate in men and women who have partial seizures with temporal lobe involvement. The Journal of clinical endocrinology and metabolism, 63(1), 243-5. https://doi.org/10.1210/jcem-63-1-243
Levesque, L A, et al. "The effect of phenytoin and carbamazepine on serum dehydroepiandrosterone sulfate in men and women who have partial seizures with temporal lobe involvement." The Journal of clinical endocrinology and metabolism vol. 63,1 (1986): 243-5. doi: https://doi.org/10.1210/jcem-63-1-243
Levesque LA, Herzog AG, Seibel MM. The effect of phenytoin and carbamazepine on serum dehydroepiandrosterone sulfate in men and women who have partial seizures with temporal lobe involvement. J Clin Endocrinol Metab. 1986 Jul;63(1):243-5. doi: 10.1210/jcem-63-1-243. PMID: 2940256.
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J Clin Endocrinol Metab. 1986 Jul;63(1):243-5. doi: 10.1210/jcem-63-1-243.

The effect of phenytoin and carbamazepine on serum dehydroepiandrosterone sulfate in men and women who have partial seizures with temporal lobe involvement.

The Journal of clinical endocrinology and metabolism

L A Levesque, A G Herzog, M M Seibel

PMID: 2940256 DOI: 10.1210/jcem-63-1-243

Abstract

In a study of 16 men and 55 women with temporal lobe epilepsy (TLE), we found that the serum dehydroepiandrosterone sulfate (DHEA-S) level was significantly lower (P less than 0.05) in patients who were treated with phenytoin (mean +/- SD DHEA-S in men, 685 +/- 429 ng/ml; in women, 580 +/- 289), carbamazepine (women, 779 +/- 529), or a combination of the two drugs (men, 491 +/- 246; women, 474 +/- 284) than in age- and sex-matched untreated patients (men, 2634 +/- 418; women, 2011 +/- 1435) or in normal subjects (men, 2870 +/- 1052; women, 1764 +/- 617). DHEA-S values in the treated groups did not differ from one another. The DHEA-S levels in untreated patients with TLE did not differ significantly from those in normal subjects. TLE alone, therefore, is unlikely to account for the decrease in DHEA-S, and thus, the results suggest that the antiseizure medications are capable of reducing DHEA-S levels. These findings are important because DHEA-S levels are often measured as part of a battery of tests to assess endocrine function in conditions such as polycystic ovarian syndrome, which may be over-represented among women with TLE.

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