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Wood NJ, Lowe AS, Walton JP. Sodium salicylate alters temporal integration measured through increasing stimulus presentation rates. Int J Audiol. 2019;58(3):141-150doi: 10.1080/14992027.2018.1544424.
Wood, N. J., Lowe, A. S., & Walton, J. P. (2019). Sodium salicylate alters temporal integration measured through increasing stimulus presentation rates. International journal of audiology, 58(3), 141-150. https://doi.org/10.1080/14992027.2018.1544424
Wood, Nicole J, et al. "Sodium salicylate alters temporal integration measured through increasing stimulus presentation rates." International journal of audiology vol. 58,3 (2019): 141-150. doi: https://doi.org/10.1080/14992027.2018.1544424
Wood NJ, Lowe AS, Walton JP. Sodium salicylate alters temporal integration measured through increasing stimulus presentation rates. Int J Audiol. 2019 Mar;58(3):141-150. doi: 10.1080/14992027.2018.1544424. PMID: 30845859; PMCID: PMC6779320.
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Int J Audiol. 2019 Mar;58(3):141-150. doi: 10.1080/14992027.2018.1544424.

Sodium salicylate alters temporal integration measured through increasing stimulus presentation rates.

International journal of audiology

Nicole J Wood, Andrea S Lowe, Joseph P Walton

Affiliations

  1. a Department of Biology , University of South Florida , Tampa , FL , USA.
  2. b Morsani College of Medicine , University of South Florida , Tampa , FL , USA.
  3. c Global Center for Hearing and Speech Research , University of South Florida , Tampa , FL , USA.
  4. d Department of Chemical and Biomedical Engineering , University of South Florida , Tampa , FL , USA.
  5. e Department of Communication Sciences and Disorders , University of South Florida , Tampa , FL , USA.

PMID: 30845859 PMCID: PMC6779320 DOI: 10.1080/14992027.2018.1544424

Abstract

OBJECTIVE: High doses of sodium salicylate (SS) are known to induce tinnitus, general hyperexcitability in the central auditory system, and to cause mild hearing loss. We used the auditory brainstem response (ABR) to assess the effects of SS on auditory sensitivity and temporal processing in the auditory nerve and brainstem. ABRs were evoked using tone burst stimuli varying in frequency and intensity with presentation rates from 11/s to 81/s.

DESIGN: ABRs were recorded and analysed prior to and after SS treatment in each animal, and peak 1 and peak 4 amplitudes and latencies were determined along with minimal response threshold.

STUDY SAMPLE: Nine young adult CBA/CaJ mice were used in a longitudinal within-subject design.

RESULTS: No measurable effects of presentation rate were found on ABR threshold prior to SS; however, following SS administration increasing stimulus rates lowered ABR thresholds by as much as 10 dB and compressed the peak amplitude by intensity level functions.

CONCLUSIONS: These results suggest that SS alters temporal integration and compressive nonlinearity, and that varying the stimulus rate of the ABR may prove to be a useful diagnostic tool in the study of hearing disorders that involve hyperexcitability.

Keywords: Auditory brainstem response (ABR); adaptation; sodium salicylate; temporal integration; tinnitus

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