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Sattler SM, Lubberding AF, Skibsbye L, et al. Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model. J Cardiovasc Transl Res. 2019;12(4):321-330doi: 10.1007/s12265-018-9861-6.
Sattler, S. M., Lubberding, A. F., Skibsbye, L., Jabbari, R., Wakili, R., Jespersen, T., & Tfelt-Hansen, J. (2019). Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model. Journal of cardiovascular translational research, 12(4), 321-330. https://doi.org/10.1007/s12265-018-9861-6
Sattler, Stefan M, et al. "Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model." Journal of cardiovascular translational research vol. 12,4 (2019): 321-330. doi: https://doi.org/10.1007/s12265-018-9861-6
Sattler SM, Lubberding AF, Skibsbye L, Jabbari R, Wakili R, Jespersen T, Tfelt-Hansen J. Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model. J Cardiovasc Transl Res. 2019 Aug;12(4):321-330. doi: 10.1007/s12265-018-9861-6. Epub 2019 Jan 07. PMID: 30617762; PMCID: PMC6707967.
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J Cardiovasc Transl Res. 2019 Aug;12(4):321-330. doi: 10.1007/s12265-018-9861-6. Epub 2019 Jan 07.

Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model.

Journal of cardiovascular translational research

Stefan M Sattler, Anniek F Lubberding, Lasse Skibsbye, Reza Jabbari, Reza Wakili, Thomas Jespersen, Jacob Tfelt-Hansen

Affiliations

  1. Department of Cardiology, Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. [email protected].
  2. Department of Medicine I, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians University Munich (LMU), Munich, Germany. [email protected].
  3. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  4. Department of Exploratory Toxicology, H. Lundbeck A/S, Valby, Denmark.
  5. Department of Cardiology, Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  6. Department of Cardiology and Vascular Medicine, West-German Heart and Vascular Center Essen, University of Essen Medical School, University Duisburg-Essen, Essen, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance (MHA), Munich, Germany.
  7. Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

PMID: 30617762 PMCID: PMC6707967 DOI: 10.1007/s12265-018-9861-6

Abstract

Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of death and treatment options are limited. The aim was to test whether early infusion of amiodarone 10 min after onset of AMI reduced the incidence of VF in a porcine model. Eighteen female Danish landrace pigs were randomized to a control and an amiodarone group. AMI was induced by ligation of the mid-left anterior descending artery for 120 min followed by 60 min of reperfusion. VF occurred in 0/8 pigs treated with amiodarone compared to 7/10 controls (P < 0.01). Amiodarone treatment prolonged RR intervals, reduced dispersion of action potential duration in the infarcted area and mean number of ectopic beats. No negative effects on cardiac output and blood pressure were observed with amiodarone. Amiodarone qualifies as a potential drug candidate to prevent VF in the first minutes to hours of AMI.

Keywords: Acute myocardial infarction; Amiodarone; Animal model; Sudden cardiac death; Ventricular fibrillation

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