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Yablonsky F, Riffaud JP, Lacolle JY, et al. Evidence for non-adrenergic binding sites for [3H]idazoxan in the smooth muscle of rabbit urethra. Eur J Pharmacol. 1988;154(2):209-12doi: 10.1016/0014-2999(88)90100-8.
Yablonsky, F., Riffaud, J. P., Lacolle, J. Y., & Dausse, J. P. (1988). Evidence for non-adrenergic binding sites for [3H]idazoxan in the smooth muscle of rabbit urethra. European journal of pharmacology, 154(2), 209-12. https://doi.org/10.1016/0014-2999(88)90100-8
Yablonsky, F, et al. "Evidence for non-adrenergic binding sites for [3H]idazoxan in the smooth muscle of rabbit urethra." European journal of pharmacology vol. 154,2 (1988): 209-12. doi: https://doi.org/10.1016/0014-2999(88)90100-8
Yablonsky F, Riffaud JP, Lacolle JY, Dausse JP. Evidence for non-adrenergic binding sites for [3H]idazoxan in the smooth muscle of rabbit urethra. Eur J Pharmacol. 1988 Sep 13;154(2):209-12. doi: 10.1016/0014-2999(88)90100-8. PMID: 2906613.
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Elsevier Science

Eur J Pharmacol. 1988 Sep 13;154(2):209-12. doi: 10.1016/0014-2999(88)90100-8.

Evidence for non-adrenergic binding sites for [3H]idazoxan in the smooth muscle of rabbit urethra.

European journal of pharmacology

F Yablonsky, J P Riffaud, J Y Lacolle, J P Dausse

Affiliations

  1. Laboratories Debat, Garches, France.

PMID: 2906613 DOI: 10.1016/0014-2999(88)90100-8

Abstract

The binding characteristics of [3H]idazoxan and [3H]rauwolscine, two potent alpha 2-adrenoceptor antagonists, were compared in the rabbit urethral smooth muscle. The maximal binding capacity was 6 times higher for [3H]idazoxan than for [3H]rauwolscine in male rabbits. No difference was observed for these radioligands in female rabbits. There were marked differences in the ability of alpha 2-adrenergic compounds to inhibit [3H]idazoxan and [3H]rauwolscine binding. These results were consistent with the existence of non-alpha 2-adrenoceptor sites for [3H]idazoxan in the rabbit urethral smooth muscle.

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