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Aspelund T, Grübler MR, Smith AV, et al. Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts. Nutrients. 2019;11(1)doi: 10.3390/nu11010074.
Aspelund, T., Grübler, M. R., Smith, A. V., Gudmundsson, E. F., Keppel, M., Cotch, M. F., Harris, T. B., Jorde, R., Grimnes, G., Joakimsen, R., Schirmer, H., Wilsgaard, T., Mathiesen, E. B., Njølstad, I., Løchen, M. L., März, W., Kleber, M. E., Tomaschitz, A., Grove-Laugesen, D., Rejnmark, L., Swart, K. M. A., Brouwer, I. A., Lips, P., van Schoor, N. M., Sempos, C. T., Durazo-Arvizu, R. A., Škrabáková, Z., Dowling, K. G., Cashman, K. D., Kiely, M., Pilz, S., Gudnason, V., & Eiriksdottir, G. (2019). Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts. Nutrients, 11(1), . https://doi.org/10.3390/nu11010074
Aspelund, Thor, et al. "Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts." Nutrients vol. 11,1 (2019). doi: https://doi.org/10.3390/nu11010074
Aspelund T, Grübler MR, Smith AV, Gudmundsson EF, Keppel M, Cotch MF, Harris TB, Jorde R, Grimnes G, Joakimsen R, Schirmer H, Wilsgaard T, Mathiesen EB, Njølstad I, Løchen ML, März W, Kleber ME, Tomaschitz A, Grove-Laugesen D, Rejnmark L, Swart KMA, Brouwer IA, Lips P, van Schoor NM, Sempos CT, Durazo-Arvizu RA, Škrabáková Z, Dowling KG, Cashman KD, Kiely M, Pilz S, Gudnason V, Eiriksdottir G. Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts. Nutrients. 2019 Jan 02;11(1). doi: 10.3390/nu11010074. PMID: 30609725; PMCID: PMC6356674.
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Nutrients. 2019 Jan 02;11(1). doi: 10.3390/nu11010074.

Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts.

Nutrients

Thor Aspelund, Martin R Grübler, Albert V Smith, Elias F Gudmundsson, Martin Keppel, Mary Frances Cotch, Tamara B Harris, Rolf Jorde, Guri Grimnes, Ragnar Joakimsen, Henrik Schirmer, Tom Wilsgaard, Ellisiv B Mathiesen, Inger Njølstad, Maja-Lisa Løchen, Winfried März, Marcus E Kleber, Andreas Tomaschitz, Diana Grove-Laugesen, Lars Rejnmark, Karin M A Swart, Ingeborg A Brouwer, Paul Lips, Natasja M van Schoor, Christopher T Sempos, Ramón A Durazo-Arvizu, Zuzana Škrabáková, Kirsten G Dowling, Kevin D Cashman, Mairead Kiely, Stefan Pilz, Vilmundur Gudnason, Gudny Eiriksdottir

Affiliations

  1. Icelandic Heart Association, 201 Kopavogur, Iceland. [email protected].
  2. Faculty of Medicine, School of Health Sciences, University of Iceland, 101 Reykjavik, Iceland. [email protected].
  3. Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria. [email protected].
  4. Department of Cardiology, Medical University of Graz, 8036 Graz, Austria. [email protected].
  5. Swiss Cardiovascular Center Bern, Department of Cardiology, Bern University Hospital, University of Bern, 3012 Bern, Switzerland. [email protected].
  6. Icelandic Heart Association, 201 Kopavogur, Iceland. [email protected].
  7. Faculty of Medicine, School of Health Sciences, University of Iceland, 101 Reykjavik, Iceland. [email protected].
  8. Icelandic Heart Association, 201 Kopavogur, Iceland. [email protected].
  9. Department of Laboratory Medicine, Paracelsus Medical University, 5020 Salzburg, Austria. [email protected].
  10. Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, MD 20892-1204, USA. [email protected].
  11. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD 20814, USA. [email protected].
  12. Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. [email protected].
  13. Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. [email protected].
  14. Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. [email protected].
  15. Tromsø Cardiovascular Research Group UNN, Department of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. [email protected].
  16. Department of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. [email protected].
  17. Brain and Circulation Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. [email protected].
  18. Department of Neurology, University Hospital of North Norway, 9038 Tromsø, Norway. [email protected].
  19. Department of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. [email protected].
  20. Department of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. [email protected].
  21. Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, 68167 Mannheim, Germany. [email protected].
  22. SYNLAB Academy, SYNLAB Holding Deutschland GmbH, P5, 7, D-68161 Mannheim or Gubener Straße 39, 86156 Augsburg, Germany. [email protected].
  23. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria. [email protected].
  24. Medical Clinic V, Mannheim Medical Faculty, University of Heidelberg, 68167 Mannheim, Germany. [email protected].
  25. NutriCard-Competence Cluster for Nutrition and Cardiovascular Health, Institute for Nutritional Science, Friedrich-Schiller-University, 07743 Jena, Germany. [email protected].
  26. Department of Cardiology, Medical University of Graz, 8036 Graz, Austria. [email protected].
  27. Specialist Clinic for Rehabilitation Bad Aussee, 8990 Bad Aussee, Austria. [email protected].
  28. Department of Internal Medicine-Cardiology, Charité University Hospital Berlin, Campus Virchow Klinikum, 10117 Berlin, Germany. [email protected].
  29. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark. [email protected].
  30. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark. [email protected].
  31. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health, 1081 Amsterdam, The Netherlands. [email protected].
  32. Department of Health Sciences, Faculty of Sciences and Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 Amsterdam, The Netherlands. [email protected].
  33. Department of Internal Medicine, Endocrine Section, VU University Medical Center, 1081 Amsterdam, The Netherlands. [email protected].
  34. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health, 1081 Amsterdam, The Netherlands. [email protected].
  35. Office of Dietary Supplements, National Institute of Health, Bethesda, MD 20892-7517, USA. [email protected].
  36. Department of Public Health Sciences, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA. [email protected].
  37. Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork T12K8AF, Ireland. [email protected].
  38. Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork T12K8AF, Ireland. [email protected].
  39. Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork T12K8AF, Ireland. [email protected].
  40. Department of Medicine, University College Cork, Cork T12K8AF, Ireland. [email protected].
  41. Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork T12K8AF, Ireland. [email protected].
  42. Irish Centre for Fetal and Neonatal Translational Research [INFANT], University College Cork, Cork T12K8AF, Ireland. [email protected].
  43. Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria. [email protected].
  44. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health, 1081 Amsterdam, The Netherlands. [email protected].
  45. Icelandic Heart Association, 201 Kopavogur, Iceland. [email protected].
  46. Faculty of Medicine, School of Health Sciences, University of Iceland, 101 Reykjavik, Iceland. [email protected].
  47. Icelandic Heart Association, 201 Kopavogur, Iceland. [email protected].

PMID: 30609725 PMCID: PMC6356674 DOI: 10.3390/nu11010074

Abstract

The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D Standardization Program. Most relevant single nucleotide polymorphisms of the genes

Keywords: Individual Participant Data; Mendelian randomization; Vitamin D; cohorts; mortality; standardized 25(OH)D

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