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Am J Physiol Regul Integr Comp Physiol. 2019 Feb 01;316(2):R172-R185. doi: 10.1152/ajpregu.00289.2018. Epub 2019 Jan 09.

AT.

American journal of physiology. Regulatory, integrative and comparative physiology

Noreen F Rossi, Zachary Zenner, Arun K Rishi, Edi Levi, Maria Maliszewska-Scislo

Affiliations

  1. Departments of Internal Medicine and Physiology, Wayne State University School of Medicine , Detroit, Michigan.
  2. John D. Dingell Veterans Administration Medical Center , Detroit, Michigan.
  3. Department of Oncology, Wayne State University School of Medicine , Detroit, Michigan.
  4. Department of Pathology, Wayne State University School of Medicine , Detroit, Michigan.

PMID: 30624974 PMCID: PMC6397354 DOI: 10.1152/ajpregu.00289.2018

Abstract

The subfornical organ (SFO), a forebrain circumventricular organ that lies outside the blood-brain barrier, has been implicated in arterial pressure and baroreflex responses to angiotensin II (ANG II). We tested whether pharmacological inhibition or selective silencing of SFO ANG II type 1 receptors (AT

Keywords: Goldblatt kidney; angiotensin II; renal sympathetic nerve activity

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