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Hammond JS, Godtliebsen F, Steigen S, et al. The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig. Clin Sci (Lond). 2019;133(1):153-166doi: 10.1042/CS20180858.
Hammond, J. S., Godtliebsen, F., Steigen, S., Guha, I. N., Wyatt, J., Revhaug, A., Lobo, D. N., & Mortensen, K. E. (2019). The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig. Clinical science (London, England : 1979), 133(1), 153-166. https://doi.org/10.1042/CS20180858
Hammond, John S, et al. "The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig." Clinical science (London, England : 1979) vol. 133,1 (2019): 153-166. doi: https://doi.org/10.1042/CS20180858
Hammond JS, Godtliebsen F, Steigen S, Guha IN, Wyatt J, Revhaug A, Lobo DN, Mortensen KE. The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig. Clin Sci (Lond). 2019 Jan 15;133(1):153-166. doi: 10.1042/CS20180858. Print 2019 Jan 15. PMID: 30606815; PMCID: PMC6331658.
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Clin Sci (Lond). 2019 Jan 15;133(1):153-166. doi: 10.1042/CS20180858. Print 2019 Jan 15.

The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig.

Clinical science (London, England : 1979)

John S Hammond, Fred Godtliebsen, Sonja Steigen, I Neil Guha, Judy Wyatt, Arthur Revhaug, Dileep N Lobo, Kim E Mortensen

Affiliations

  1. Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre, Nottingham, U.K.
  2. Department of Hepato-Pancreatico-Biliary Surgery and Transplantation, Freeman Hospital, Newcastle upon Tyne, U.K.
  3. Department of Mathematics and Statistics, UiT - The Arctic University of Norway, Tromsø, Norway.
  4. Institute of Medical Biology, UiT - The Arctic University of Norway, Tromsø, Norway.
  5. Department of Clinical Pathology, The University Hospital of North Norway, Tromsø, Norway.
  6. Department of Pathology, Leeds Teaching Hospitals NHS Trust, Leeds, U.K.
  7. Surgical Research Laboratory, Institute of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.
  8. Department of Gastrointestinal Surgery, The University Hospital of North Norway, Tromsø, Norway.
  9. Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre, Nottingham, U.K. [email protected].
  10. MRC/ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, U.K.

PMID: 30606815 PMCID: PMC6331658 DOI: 10.1042/CS20180858

Abstract

Liver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis, and when PVP is reduced, rates of liver dysfunction decrease. The aim of the present study was to characterize the hemodynamic, biochemical, and histological changes induced by 80% hepatectomy in non-cirrhotic pigs and determine if terlipressin or direct portacaval shunting can modulate these effects. Pigs were randomized (

© 2019 The Author(s).

Keywords: portacaval shunt; post-resection liver failure; terlipressin

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