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J Endocr Soc. 2018 Dec 03;3(1):291-303. doi: 10.1210/js.2018-00205. eCollection 2019 Jan 01.

Cardiovascular Risk Factors and Dehydroepiandrosterone Sulfate Among Latinos in the Boston Puerto Rican Health Study.

Journal of the Endocrine Society

Monik C Jiménez, Katherine L Tucker, Fátima Rodriguez, Bianca C Porneala, James B Meigs, Lenny López

Affiliations

  1. Division of Women's Health, Brigham and Women's Hospital, Boston, Massachusetts.
  2. Department of Medicine, Harvard Medical School, Boston, Massachusetts.
  3. Clinical Laboratory and Nutritional Sciences, University of Massachusetts Lowell, Lowell, Massachusetts.
  4. Division of Cardiovascular Medicine, Stanford University, Palo Alto, California.
  5. Division of General Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts.
  6. Division of Hospital Medicine, University of California San Francisco, San Francisco, California.

PMID: 30623167 PMCID: PMC6320241 DOI: 10.1210/js.2018-00205

Abstract

Low blood dehydroepiandrosterone sulfate (DHEAS) levels have strong positive associations with stroke and coronary heart disease. However, it is unclear whether DHEAS is independently associated with cardiovascular risk factors. Therefore, we examined the association between cardiovascular risk factors and DHEAS concentration among a high-risk population of Latinos (Puerto Ricans aged 45 to 75 years at baseline) in a cross-sectional analysis of the Boston Puerto Rican Health Study. Of eligible participants, 72% completed baseline interviews and provided blood samples. Complete data were available for 1355 participants. Associations between cardiovascular risk factors (age, sex, total cholesterol, high-density lipid cholesterol, triglycerides, and glucose) and log-transformed DHEAS (μg/dL) were assessed. In robust multivariable regression analyses, DHEAS was significantly inversely associated with age (

Keywords: Latino; cardiovascular risk factors; dehydroepiandrosterone sulfate

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