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Vô B, Yombi JC, Aydin S, et al. TINU-associated Fanconi syndrome: a case report and review of literature. BMC Nephrol. 2018;19(1):274doi: 10.1186/s12882-018-1077-0.
Vô, B., Yombi, J. C., Aydin, S., Demoulin, N., & Yildiz, H. (2018). TINU-associated Fanconi syndrome: a case report and review of literature. BMC nephrology, 19(1), 274. https://doi.org/10.1186/s12882-018-1077-0
Vô, Bernard, et al. "TINU-associated Fanconi syndrome: a case report and review of literature." BMC nephrology vol. 19,1 (2018): 274. doi: https://doi.org/10.1186/s12882-018-1077-0
Vô B, Yombi JC, Aydin S, Demoulin N, Yildiz H. TINU-associated Fanconi syndrome: a case report and review of literature. BMC Nephrol. 2018 Oct 19;19(1):274. doi: 10.1186/s12882-018-1077-0. PMID: 30340545; PMCID: PMC6194638.
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BMC Nephrol. 2018 Oct 19;19(1):274. doi: 10.1186/s12882-018-1077-0.

TINU-associated Fanconi syndrome: a case report and review of literature.

BMC nephrology

Bernard Vô, Jean Cyr Yombi, Selda Aydin, Nathalie Demoulin, Halil Yildiz

Affiliations

  1. Department of internal medicine and infectious diseases, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 10 Av. Hippocrate, 1200, Brussels, Belgium.
  2. Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 10 Av. Hippocrate, 1200, Brussels, Belgium.
  3. Department of internal medicine and infectious diseases, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 10 Av. Hippocrate, 1200, Brussels, Belgium. [email protected].
  4. Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 10 Av. Hippocrate, 1200, Brussels, Belgium. [email protected].
  5. Department of pathology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 10 Av. Hippocrate, 1200, Brussels, Belgium.
  6. Division of Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 10 Av. Hippocrate, 1200, Brussels, Belgium.

PMID: 30340545 PMCID: PMC6194638 DOI: 10.1186/s12882-018-1077-0

Abstract

BACKGROUND: Tubulo-interstitial Nephritis and Uveitis (TINU) syndrome is a rare oculo-renal inflammatory disease. Renal tubular defects are usually found, but full proximal tubular abnormalities have rarely been described.

CASE PRESENTATION: We report the case of a 55-year old woman, native from Morocco, presenting with bilateral, non-granulomatous, anterior uveitis, mild renal insufficiency, leucocyturia and glycosuria. Further work-up showed hypophosphatemia and hyperphosphaturia, hypouricemia and hyperuricosuria, and hyper aminoaciduria, consistent with Fanconi syndrome. A kidney biopsy was obtained and showed diffuse interstitial infiltrates with tubular necrosis. The patient improved after the initiation of a corticosteroid therapy, with tapering dose.

CONCLUSIONS: We reviewed the literature and found nine similar cases. This association mostly occurs in adult woman, without current evidence for an ethnic predilection, unlike previously reported. The renal prognosis seems favorable after corticosteroid therapy, even in case of severe renal injury. Nonetheless mild tubular defects may persist after treatment or spontaneous remission.

Keywords: Fanconi syndrome; Nephritis, interstitial; Tubulointerstitial nephritis and uveitis; Uveitis

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