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Kivelä L, Popp A, Arvola T, et al. Long-term health and treatment outcomes in adult coeliac disease patients diagnosed by screening in childhood. United European Gastroenterol J. 2018;6(7):1022-1031doi: 10.1177/2050640618778386.
Kivelä, L., Popp, A., Arvola, T., Huhtala, H., Kaukinen, K., & Kurppa, K. (2018). Long-term health and treatment outcomes in adult coeliac disease patients diagnosed by screening in childhood. United European gastroenterology journal, 6(7), 1022-1031. https://doi.org/10.1177/2050640618778386
Kivelä, Laura, et al. "Long-term health and treatment outcomes in adult coeliac disease patients diagnosed by screening in childhood." United European gastroenterology journal vol. 6,7 (2018): 1022-1031. doi: https://doi.org/10.1177/2050640618778386
Kivelä L, Popp A, Arvola T, Huhtala H, Kaukinen K, Kurppa K. Long-term health and treatment outcomes in adult coeliac disease patients diagnosed by screening in childhood. United European Gastroenterol J. 2018 Aug;6(7):1022-1031. doi: 10.1177/2050640618778386. Epub 2018 May 17. PMID: 30228890; PMCID: PMC6137595.
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United European Gastroenterol J. 2018 Aug;6(7):1022-1031. doi: 10.1177/2050640618778386. Epub 2018 May 17.

Long-term health and treatment outcomes in adult coeliac disease patients diagnosed by screening in childhood.

United European gastroenterology journal

Laura Kivelä, Alina Popp, Taina Arvola, Heini Huhtala, Katri Kaukinen, Kalle Kurppa

Affiliations

  1. Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland.
  2. Department of Pediatrics, Hospital District of South Ostrobothnia, Seinäjoki, Finland.
  3. Institute for Mother and Child Health Bucharest, University of Medicine and Pharmacy 'Carol Davila', Bucharest, Romania.
  4. Department of Pediatrics, Hospital District of Kanta-Häme, Hämeenlinna, Finland.
  5. Faculty of Social Sciences, University of Tampere, Tampere, Finland.
  6. Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.
  7. Celiac Disease Research Center, University of Tampere, Tampere, Finland.

PMID: 30228890 PMCID: PMC6137595 DOI: 10.1177/2050640618778386

Abstract

BACKGROUND: The diagnostic yield of coeliac disease could be improved by screening in at-risk groups, but long-term benefits of this approach are obscure.

OBJECTIVE: To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screening.

METHODS: After thorough evaluation of medical history, follow-up questionnaires were sent to 559 adults with a childhood coeliac disease diagnosis. The results were compared between screen-detected and clinically-detected patients, and also between originally asymptomatic and symptomatic screen-detected patients.

RESULTS: In total, 236 (42%) patients completed the questionnaires a median of 18.5 years after childhood diagnosis. Screen-detected patients (

CONCLUSION: Comparable long-term outcomes between screen-detected and clinically-detected patients support risk-group screening for coeliac disease. However, asymptomatic patients may require special attention.

Keywords: Children; diagnosis; gluten-free diet; long-term follow-up; quality of life; screening

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