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Zhu MR, Zhou J, Jin Y, et al. A manganese-salen complex as dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Int J Biol Macromol. 2018;120:1232-1239doi: 10.1016/j.ijbiomac.2018.08.089.
Zhu, M. R., Zhou, J., Jin, Y., Gao, L. H., Li, L., Yang, J. R., Lu, C. M., Zhao, Q. H., & Xie, M. J. (2018). A manganese-salen complex as dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. International journal of biological macromolecules, 1201232-1239. https://doi.org/10.1016/j.ijbiomac.2018.08.089
Zhu, Ming-Rong, et al. "A manganese-salen complex as dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes." International journal of biological macromolecules vol. 120 (2018): 1232-1239. doi: https://doi.org/10.1016/j.ijbiomac.2018.08.089
Zhu MR, Zhou J, Jin Y, Gao LH, Li L, Yang JR, Lu CM, Zhao QH, Xie MJ. A manganese-salen complex as dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Int J Biol Macromol. 2018 Dec;120:1232-1239. doi: 10.1016/j.ijbiomac.2018.08.089. Epub 2018 Aug 29. PMID: 30171949.
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Int J Biol Macromol. 2018 Dec;120:1232-1239. doi: 10.1016/j.ijbiomac.2018.08.089. Epub 2018 Aug 29.

A manganese-salen complex as dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

International journal of biological macromolecules

Ming-Rong Zhu, Jie Zhou, Yi Jin, Li-Hui Gao, Ling Li, Jun-Ru Yang, Chun-Mei Lu, Qi Hua Zhao, Ming-Jin Xie

Affiliations

  1. School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China.
  2. Biomedical Engineering Research Center, Kunming Medical University, Kunming 650500, China.
  3. School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, China. Electronic address: [email protected].

PMID: 30171949 DOI: 10.1016/j.ijbiomac.2018.08.089

Abstract

A manganese Schiff base complex with N,N'-1,2-phenylenediamine-bis(salicyladimine) was synthesized and characterized by X-ray crystallography. This complex was administered intragastrically to alloxan-diabetic mice 3 weeks. In vivo tests showed that the complex significantly lowered serum glucose levels in alloxan-diabetic mice at doses of 77 mg V kg

Copyright © 2018 Elsevier B.V. All rights reserved.

Keywords: Dipeptidyl peptidase IV; Enzyme inhibitors; Manganese(II); Molecular docking; Schiff base complex

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