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Saputri FA, Kang D, Kusuma ASW, et al. Lactobacillus plantarum IS-10506 probiotic administration increases amlodipine absorption in a rabbit model. J Int Med Res. 2018;46(12):5004-5010doi: 10.1177/0300060518788994.
Saputri, F. A., Kang, D., Kusuma, A. S. W., Rusdiana, T., Hasanah, A. N., Mutakin, Surono, I. S., Koyama, H., & Abdulah, R. (2018). Lactobacillus plantarum IS-10506 probiotic administration increases amlodipine absorption in a rabbit model. The Journal of international medical research, 46(12), 5004-5010. https://doi.org/10.1177/0300060518788994
Saputri, Febrina A, et al. "Lactobacillus plantarum IS-10506 probiotic administration increases amlodipine absorption in a rabbit model." The Journal of international medical research vol. 46,12 (2018): 5004-5010. doi: https://doi.org/10.1177/0300060518788994
Saputri FA, Kang D, Kusuma ASW, Rusdiana T, Hasanah AN, Mutakin, Surono IS, Koyama H, Abdulah R. Lactobacillus plantarum IS-10506 probiotic administration increases amlodipine absorption in a rabbit model. J Int Med Res. 2018 Dec;46(12):5004-5010. doi: 10.1177/0300060518788994. Epub 2018 Aug 09. PMID: 30092663; PMCID: PMC6300973.
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J Int Med Res. 2018 Dec;46(12):5004-5010. doi: 10.1177/0300060518788994. Epub 2018 Aug 09.

Lactobacillus plantarum IS-10506 probiotic administration increases amlodipine absorption in a rabbit model.

The Journal of international medical research

Febrina A Saputri, Devinna Kang, Arif S W Kusuma, Taofik Rusdiana, Aliya N Hasanah, Mutakin, Ingrid S Surono, Hiroshi Koyama, Rizky Abdulah

Affiliations

  1. 1 Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia.
  2. 2 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia.
  3. 3 Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia.
  4. 4 Department of Pharmaceutical and Formulation Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia.
  5. 5 Department of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta, Indonesia.
  6. 6 Department of Public Health, Gunma University Graduate School of Medicine, Gunma, Japan.

PMID: 30092663 PMCID: PMC6300973 DOI: 10.1177/0300060518788994

Abstract

OBJECTIVE: Probiotics are beneficial in human health. In this study, we investigated the effect of probiotics on absorption of amlodipine, a dihydropyridine calcium antagonist used in the treatment of angina and hypertension, in a rabbit model.

METHODS: Lactobacillus plantarum IS-10506 probiotic was administered for 14 days to male New Zealand rabbits. Blood samples were collected before and after probiotic supplementation. Amlodipine (10 mg) was then administered to all groups. Blood samples from a marginal vein were withdrawn at 5, 15, 30, 60, and 120 minutes to determine amlodipine concentrations in rabbit plasma.

RESULTS: Amlodipine concentrations in the L. plantarum IS-10506 group were 4.95 ± 1.22, 8.71 ± 0.69, and 12.48 ± 2.53 ng/ml, and those in the control group were 1.69 ± 0.31, 3.89 ± 1.23, and 7.17 ± 1.85 ng/ml at 30, 60, and 120 minutes, respectively after administration of amlodipine. Amlodipine concentrations in the L. plantarum IS-10506 group were significantly higher than those in the control group at 30, 60, and 120 minutes after amlodipine administration.

CONCLUSION: Our results suggested that supplementation of L. plantarum IS-10506 significantly increases amlodipine plasma concentrations in rabbits.

Keywords: ; Probiotic; absorption; amlodipine; calcium channel blocker; dadih; gastrointestinal tract; hematology

References

  1. Arch Toxicol. 2000 Sep;74(7):379-87 - PubMed
  2. J Pharm Sci. 1975 Apr;64(4):664-71 - PubMed
  3. J Food Prot. 2007 Mar;70(3):700-5 - PubMed
  4. Front Neurosci. 2015 Jan 20;8:452 - PubMed
  5. J Clin Pharmacol. 2002 Jun;42(6):620-43 - PubMed
  6. Drugs. 1995 Sep;50(3):560-86 - PubMed
  7. J Trace Elem Med Biol. 2014 Oct;28(4):465-9 - PubMed
  8. Pharmacogenomics. 2008 Jan;9(1):105-27 - PubMed
  9. Nat Rev Gastroenterol Hepatol. 2010 Sep;7(9):503-14 - PubMed
  10. J Exp Biol. 2009 Nov;212(Pt 21):3387-93 - PubMed
  11. J Cardiovasc Pharmacol. 1988;12 Suppl 7:S55-9 - PubMed
  12. Pharm Sci Technolo Today. 2000 Apr;3(4):138-145 - PubMed
  13. PLoS One. 2014 Feb 05;9(2):e87150 - PubMed
  14. Eur J Drug Metab Pharmacokinet. 2008 Apr-Jun;33(2):101-6 - PubMed
  15. Appl Microbiol Biotechnol. 2008 Dec;81(4):591-606 - PubMed
  16. J Pharm Biomed Anal. 1991;9(7):565-71 - PubMed
  17. Br J Nutr. 2002 Sep;88 Suppl 1:S39-49 - PubMed
  18. Immunology. 2017 Sep;152(1):1-12 - PubMed

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