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Sanagapalli S, Ko Y, Kariyawasam V, et al. The association between new generation oral contraceptive pill and the development of inflammatory bowel diseases. Intest Res. 2018;16(3):409-415doi: 10.5217/ir.2018.16.3.409.
Sanagapalli, S., Ko, Y., Kariyawasam, V., Ng, S. C., Tang, W., de Silva, H. J., Chen, M., Wu, K., Aniwan, S., Ng, K. K., Ong, D., Ouyang, Q., Hilmi, I., Simadibrata, M., Pisespongsa, P., Gopikrishna, S., Leong, R. W. (2018). The association between new generation oral contraceptive pill and the development of inflammatory bowel diseases. Intestinal research, 16(3), 409-415. https://doi.org/10.5217/ir.2018.16.3.409
Sanagapalli, Santosh, et al. "The association between new generation oral contraceptive pill and the development of inflammatory bowel diseases." Intestinal research vol. 16,3 (2018): 409-415. doi: https://doi.org/10.5217/ir.2018.16.3.409
Sanagapalli S, Ko Y, Kariyawasam V, Ng SC, Tang W, de Silva HJ, Chen M, Wu K, Aniwan S, Ng KK, Ong D, Ouyang Q, Hilmi I, Simadibrata M, Pisespongsa P, Gopikrishna S, Leong RW. The association between new generation oral contraceptive pill and the development of inflammatory bowel diseases. Intest Res. 2018 Jul;16(3):409-415. doi: 10.5217/ir.2018.16.3.409. Epub 2018 Jul 27. PMID: 30090040; PMCID: PMC6077300.
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Intest Res. 2018 Jul;16(3):409-415. doi: 10.5217/ir.2018.16.3.409. Epub 2018 Jul 27.

The association between new generation oral contraceptive pill and the development of inflammatory bowel diseases.

Intestinal research

Santosh Sanagapalli, Yanna Ko, Viraj Kariyawasam, Siew C Ng, Whitney Tang, Hithanadura Janaka de Silva, Minhu Chen, Kaichun Wu, Satimai Aniwan, Ka Kei Ng, David Ong, Qin Ouyang, Ida Hilmi, Marcellus Simadibrata, Pises Pisespongsa, Saranya Gopikrishna, Rupert W Leong,

Affiliations

  1. Gastroenterology and Liver Services, Concord Repatriation General Hospital, Concord NSW, Australia.
  2. Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Science, Hong Kong, China.
  3. Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
  4. The First Affiliated Hospital of Sun Yat Sen University, Guangzhou, China.
  5. Xijing Hospital, Fourth Military Medical University, Xian, China.
  6. King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
  7. Hospital Conde S Januario, Macau, China.
  8. National University Hospital of Singapore, Singapore.
  9. West China Hospital, Sichuan University, Chengdu, China.
  10. University of Malaya Medical Center, Kuala Lumpur, Malaysia.
  11. University of Indonesia, Indonesia.
  12. Maharaj Nakorn Chiangmai Hospital, Chiangmai, Thailand.

PMID: 30090040 PMCID: PMC6077300 DOI: 10.5217/ir.2018.16.3.409

Abstract

BACKGROUND/AIMS: To examine the association between use of oral contraceptive pills (OCPs) and the risk of developing inflammatory bowel diseases (IBD), in a modern cohort.

METHODS: A prospective nested case-control study across sites in the Asia-Pacific region was conducted; involving female IBD cases and asymptomatic controls. Subjects completed a questionnaire addressing questions related to OCP use. Primary outcome was the risk of development of IBD of those exposed to OCP versus non-exposure. Secondary outcomes were development of Crohn's disease (CD) versus ulcerative colitis (UC), and whether age of first use of OCP use may be associated with risk of IBD.

RESULTS: Three hundred and forty-eight female IBD cases (41% CD, median age: 43 years) and 590 female age-matched controls were recruited. No significant association was found between OCP use and the risk of IBD (odds ratio [OR], 1.65; 95% confidence interval, 0.77-3.13;

CONCLUSIONS: In this large cohort of subjects from the Asia-Pacific region, we found a modest but not significantly increased risk of developing IBD amongst OCP users.

Keywords: Contraceptives, oral; Inflammatory bowel diseases

Conflict of interest statement

CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported.

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