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Li RC, Ke S, Meng FK, et al. CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13. Cell Death Dis. 2018;9(8):838doi: 10.1038/s41419-018-0852-y.
Li, R. C., Ke, S., Meng, F. K., Lu, J., Zou, X. J., He, Z. G., Wang, W. F., & Fang, M. H. (2018). CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13. Cell death & disease, 9(8), 838. https://doi.org/10.1038/s41419-018-0852-y
Li, Rui-Chao, et al. "CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13." Cell death & disease vol. 9,8 (2018): 838. doi: https://doi.org/10.1038/s41419-018-0852-y
Li RC, Ke S, Meng FK, Lu J, Zou XJ, He ZG, Wang WF, Fang MH. CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13. Cell Death Dis. 2018 Aug 06;9(8):838. doi: 10.1038/s41419-018-0852-y. PMID: 30082829; PMCID: PMC6079012.
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Cell Death Dis. 2018 Aug 06;9(8):838. doi: 10.1038/s41419-018-0852-y.

CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13.

Cell death & disease

Rui-Chao Li, Shun Ke, Fan-Kai Meng, Jun Lu, Xiao-Jing Zou, Zhi-Gang He, Weng-Feng Wang, Ming-Hao Fang

Affiliations

  1. Department of General Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  2. Department of Emergency Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  3. Department of hematology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China.
  4. Department of Cardiovascular Medicine, Ezhou Central Hospital of Hubei, Ezhou, 436000, China.
  5. Department of Emergency Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China. [email protected].

PMID: 30082829 PMCID: PMC6079012 DOI: 10.1038/s41419-018-0852-y

Abstract

The circular RNA ciRS-7 has been reported to be involved in the pathogenesis of various tumors, including gastric and colorectal cancer. However, the role of ciRS-7 in esophageal squamous cell carcinoma (ESCC) remains unsolved. In this study, we found that the ciRS-7 expression was significantly upregulated in ESCC cancer tissues compared with matched normal tissues and associated with poor patient survival. Overexpression of ciRS-7 abrogated the tumor-suppressive roles of miR-7 including cell proliferation, migration and invasion in vitro as well as tumor growth and lung metastasis in vivo. Mechanistically, ciRS-7 functioned as the sponge of miR-7 and reactivated its downstream HOXB13-mediated NF-κB/p65 pathway. Conclusively, our findings demonstrate how ciRS-7 induces malignant progression of ESCC and that ciRS-7 may act as a novel prognostic marker and therapeutic target for this lethal disease.

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