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Deng T, Li Y, Jolliff K, et al. The mouse thymidylate synthase promoter: essential elements are in close proximity to the transcriptional initiation sites. Mol Cell Biol. 1989;9(9):4079-82doi: 10.1128/mcb.9.9.4079-4082.1989.
Deng, T., Li, Y., Jolliff, K., & Johnson, L. F. (1989). The mouse thymidylate synthase promoter: essential elements are in close proximity to the transcriptional initiation sites. Molecular and cellular biology, 9(9), 4079-82. https://doi.org/10.1128/mcb.9.9.4079-4082.1989
Deng, T, et al. "The mouse thymidylate synthase promoter: essential elements are in close proximity to the transcriptional initiation sites." Molecular and cellular biology vol. 9,9 (1989): 4079-82. doi: https://doi.org/10.1128/mcb.9.9.4079-4082.1989
Deng T, Li Y, Jolliff K, Johnson LF. The mouse thymidylate synthase promoter: essential elements are in close proximity to the transcriptional initiation sites. Mol Cell Biol. 1989 Sep;9(9):4079-82. doi: 10.1128/mcb.9.9.4079-4082.1989. PMID: 2779579; PMCID: PMC362476.
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Atypon Free PMC Article

Mol Cell Biol. 1989 Sep;9(9):4079-82. doi: 10.1128/mcb.9.9.4079-4082.1989.

The mouse thymidylate synthase promoter: essential elements are in close proximity to the transcriptional initiation sites.

Molecular and cellular biology

T Deng, Y Li, K Jolliff, L F Johnson

Affiliations

  1. Department of Biochemistry, Ohio State University, Columbus 43210.

PMID: 2779579 PMCID: PMC362476 DOI: 10.1128/mcb.9.9.4079-4082.1989
Free PMC Article

Abstract

The promoter region of the mouse thymidylate synthase gene was analyzed by deletion and site-directed mutagenesis. Elimination of an upstream Sp1 element reduced expression threefold, whereas elimination of an adenovirus upstream stimulatory factor element had little effect. All of the upstream elements that are essential for promoter activity are located within 22 nucleotides of the first transcriptional initiation site.

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