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Front Neurosci. 2018 Jun 14;12:403. doi: 10.3389/fnins.2018.00403. eCollection 2018.

The Stability and Repeatability of Spontaneous Sympathetic Baroreflex Sensitivity in Healthy Young Individuals.

Frontiers in neuroscience

Sarah L Hissen, Khadigeh El Sayed, Vaughan G Macefield, Rachael Brown, Chloe E Taylor

Affiliations

  1. School of Science and Health, Western Sydney University, Sydney, NSW, Australia.
  2. School of Medicine, Western Sydney University, Sydney, NSW, Australia.
  3. Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  4. Neuroscience Research Australia, Sydney, NSW, Australia.

PMID: 29962929 PMCID: PMC6010576 DOI: 10.3389/fnins.2018.00403

Abstract

Spontaneous sympathetic baroreflex sensitivity (BRS) is a valuable tool for assessing how well the baroreflex buffers beat-to-beat changes in blood pressure. However, there has yet to be a study involving appropriate statistical tests to examine the stability of sympathetic BRS within an experimental session and the repeatability between separate sessions. The aim of this study was to use intra-class correlations, ordinary least products regression, and Bland-Altman analyses to examine the stability and repeatability of spontaneous sympathetic BRS assessment. In addition, the influence of recording duration on values of BRS was assessed. In eighty-four healthy young individuals (49 males, 35 females), continuous measurements of blood pressure, heart rate and muscle sympathetic nerve activity (MSNA) were recorded for 10 min. In a subgroup of 13 participants (11 male, 2 female) the measurements were repeated on a separate day. Sympathetic BRS was quantified using MSNA burst incidence (BRS

Keywords: baroreflex sensitivity; blood pressure; microneurography; muscle sympathetic nerve activity; repeatability

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